ArticleCurrent biology : CB2016
Effective Modulation of Male Aggression through Lateral Septum to Medial Hypothalamus Projection.
Article in Current biology : CB, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers.
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Who cites it
97 citing papers in PubMed.
- The Molecular Architecture of Somatic Spines of the Lateral Septum.The Journal of comparative neurology · 2026Article
- Hypothalamic representation of aggressiveness across mouse strains.Nature communications · 2026Article
- Article
- Neural basis of social hierarchy across species.Nature reviews. Neuroscience · 2026Review
- Timed melatonin administration increases territorial but not non-territorial aggression in female Siberian hamsters.Hormones and behavior · 2026Article
- Lateral septum GABAergic neurons mediate the effects of dexmedetomidine on allodynia and sleep in a male mouse model of neuropathic pain.Nature communications · 2026Article
- The hormonal and neural control of maternal aggression.Current opinion in neurobiology · 2026Review
- Ventromedial hypothalamus IL-6 signaling mediates the excessive aggressive behavior induced by late-gestational sleep deprivation in male mice.Behavioral and brain functions : BBF · 2026Article
- Dopamine modulation of aggression.Psychopharmacology · 2026Review
- Bidirectional regulation of social memory by two distinct types of GABAergic neurons in the lateral septum.Nature communications · 2026Article
- Novel object recognition in the dorsomedial and ventral hippocampus of young domestic chicks (Gallus gallus).Brain structure & function · 2026Article
- Shedding light on social dominance within the affective neuroscience personality scales.Personality neuroscience · 2026Article
- Circuit logic of oxytocin and vasopressin complementary actions.Frontiers in neuroscience · 2026Review
- Sex differences in the neural circuitry of aggression.bioRxiv : the preprint server for biology · 2025Article
- Thalamo-hippocampal pathway determines aggression and self-harm.Science advances · 2025Article
- Organization of Brainwide Inputs to Discrete Lateral Septum Projection Populations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Opioid-driven disruption of the septum reveals a role for neurotensin-expressing neurons in withdrawal.Neuron · 2025Article
- Modulation of aggression by social novelty recognition memory in the hippocampal CA2 region.Cell reports · 2025Article
- Brain circuits that regulate social behavior.Molecular psychiatry · 2025Review
- Article
37 more citing papers are in PubMed but not listed here.
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Authors and funding
12 authors.
Funding
Abstract
Aggression is a prevalent behavior in the animal kingdom that is used to settle competition for limited resources. Given the high risk associated with fighting, the central nervous system has evolved an active mechanism to modulate its expression. Lesioning the lateral septum (LS) is known to cause "septal rage," a phenotype characterized by a dramatic increase in the frequency of attacks. To understand the circuit mechanism of LS-mediated modulation of aggression, we examined the influence of LS input on the cells in and around the ventrolateral part of the ventromedial hypothalamus (VMHvl)-a region required for male mouse aggression. We found that the inputs from the LS inhibited the attack-excited cells but surprisingly increased the overall activity of attack-inhibited cells. Furthermore, optogenetic activation of the projection from LS cells to the VMHvl terminated ongoing attacks immediately but had little effect on mounting. Thus, LS projection to the ventromedial hypothalamic area represents an effective pathway for suppressing male aggression.
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