ArticleScientific reports2016
Probing the phenomenon of trained immunity in invertebrates during a transgenerational study, using brine shrimp Artemia as a model system.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 94 citations in OpenAlex.
- Rethinking Disease Control in Aquaculture Invertebrates: Harnessing Innate Immunity in Molluscs and Crustaceans.Pathogens (Basel, Switzerland) · 2026Review
- Carvacrol as a one health-relevant antimicrobial agent: mechanistic insights on its impact on gnotobiotic Artemia and Vibrio campbellii interactions.Frontiers in immunology · 2026Article
- Improving the odds of survival: transgenerational effects of infections.EMBO molecular medicine · 2025Review
- Evidence for trans-generational immune priming againstFrontiers in immunology · 2025Article
- Macrophage memories of early-life injury drive neonatal nociceptive priming.Cell reports · 2024Article
- Experimental Infection Models and Their Usefulness for White Spot Syndrome Virus (WSSV) Research in Shrimp.Viruses · 2024Review
- Invertebrate Immunity, Natural Transplantation Immunity, Somatic and Germ Cell Parasitism, and Transposon Defense.International journal of molecular sciences · 2024Review
- Disentangling specific and unspecific components of innate immune memory in a copepod-tapeworm system.Frontiers in immunology · 2024Article
- Trained immunity in diabetes and hyperlipidemia: Emerging opportunities to target cardiovascular complications and design new therapies.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023Review
- Developmental impact of peripheral injury on neuroimmune signaling.Brain, behavior, and immunity · 2023Review
- Review
- Priming European Sea Bass Female Broodstock Improves the Antimicrobial Immunity of Their Offspring.Animals : an open access journal from MDPI · 2023Article
- The mechanisms and factors that induce trained immunity in arthropods and mollusks.Frontiers in immunology · 2023Review
- Heat Shock Proteins (Hsps) in Cellular Homeostasis: A Promising Tool for Health Management in Crustacean Aquaculture.Life (Basel, Switzerland) · 2022Review
- Host-pathogen coevolution drives innate immune response to Aphanomyces astaci infection in freshwater crayfish: transcriptomic evidence.BMC genomics · 2022Article
- Early life microbial exposures shape the Crassostrea gigas immune system for lifelong and intergenerational disease protection.Microbiome · 2022Article
- Studying phenotypic variation and DNA methylation across development, ecology and evolution in the clonal marbled crayfish: a paradigm for investigating epigenotype-phenotype relationships in macro-invertebrates.Die Naturwissenschaften · 2022Review
- Review
- Metabolomic Investigation of Ultraviolet Ray-Inactivated White Spot Syndrome Virus-Induced Trained Immunity inFrontiers in immunology · 2022Article
- Transmission of trained immunity and heterologous resistance to infections across generations.Nature immunology · 2021Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The invertebrate's innate immune system was reported to show some form of adaptive features, termed trained immunity. However, the memory characteristics of innate immune system and the mechanisms behind such phenomena remain unclear. Using the invertebrate model Artemia, we verified the possibility or impossibility of trained immunity, examining the presence or absence of enduring memory against homologous and heterologous antigens (Vibrio spp.) during a transgenerational study. We also determined the mechanisms behind such phenomenon. Our results showed the occurrence of memory and partial discrimination in Artemia's immune system, as manifested by increased resistance, for three successive generations, of the progenies of Vibrio-exposed ancestors towards a homologous bacterial strain, rather than to a heterologous strain. This increased resistance phenotype was associated with elevated levels of hsp70 and hmgb1 signaling molecules and alteration in the expression of key innate immunity-related genes. Our results also showed stochastic pattern in the acetylation and methylation levels of H4 and H3K4me3 histones, respectively, in the progenies whose ancestors were challenged. Overall results suggest that innate immune responses in invertebrates have the capacity to be trained, and epigenetic reprogramming of (selected) innate immune effectors is likely to have central place in the mechanisms leading to trained immunity.
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