Trial reportMechanisms of ageing and development2016
Longitudinal telomere length shortening and cognitive and physical decline in later life: The Lothian Birth Cohorts 1936 and 1921.
Trial report in Mechanisms of ageing and development, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Systematic Review of Pulmonary Function and Cognition in Aging.The journals of gerontology. Series B, Psychological sciences and social sciences · 2020Pooled it
- Association of telomere length with general cognitive trajectories: a meta-analysis of four prospective cohort studies.Neurobiology of aging · 2018Pooled it
- Short telomere length is associated with impaired cognitive performance in European ancestry cohorts.Translational psychiatry · 2017Pooled it
- Effects of Meditation and Music-Listening on Blood Biomarkers of Cellular Aging and Alzheimer's Disease in Adults with Subjective Cognitive Decline: An Exploratory Randomized Clinical Trial.Journal of Alzheimer's disease : JAD · 2018Trial
- Multimodal Ageing Biomarkers and Plasma Proteomic Signatures Associated With All-Cause Mortality.Aging cell · 2026Article
- Epigenetic age acceleration, telomere length, and neurocognitive function in long-term survivors of childhood cancer.Nature communications · 2025Article
- Lessons we learned from the Lothian Birth Cohorts of 1921 and 1936.Genomic psychiatry : advancing science from genes to society · 2025Article
- Effects of gene dosage on cognitive ability: A function-based association study across brain and non-brain processes.Cell genomics · 2024Article
- Dynamics of Leukocyte Telomere Length in Patients with Fabry Disease.Biomedicines · 2024Article
- Work-Related Psychosocial Factors and Global Cognitive Function: Are Telomere Length and Low-Grade Inflammation Potential Mediators of This Association?International journal of environmental research and public health · 2023Article
- Longitudinal telomere length profile does not reflect HIV and childhood trauma impacts on cognitive function in South African women.Journal of neurovirology · 2021Article
- Short Leukocyte Telomeres, But Not Telomere Attrition Rates, Predict Memory Decline in the 20-Year Longitudinal Betula Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Dynamics of leukocyte telomere length in adults aged 50 and older: a longitudinal population-based cohort study.GeroScience · 2021Article
- The associations of hostility and defensiveness with telomere length are influenced by sex and health status.Biology of sex differences · 2021Article
- Midlife Leukocyte Telomere Length as an Indicator for Handgrip Strength in Late Life.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Seasonal variation in telomere dynamics in African striped mice.Oecologia · 2020Article
- Leukocyte Telomere Length Is Unrelated to Cognitive Performance Among Non-Demented and Demented Persons: An Examination of Long Life Family Study Participants.Journal of the International Neuropsychological Society : JINS · 2020Article
- Attitudes to ageing, biomarkers of ageing and mortality: the Lothian Birth Cohort 1936.Journal of epidemiology and community health · 2020Article
- Article
- Telomere Attrition in Neurodegenerative Disorders.Frontiers in cellular neuroscience · 2020Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Telomere length is hypothesised to be a biological marker of both cognitive and physical ageing. Here we measure telomere length, and cognitive and physical abilities at mean ages 70, 73 and 76 years in the Lothian Birth Cohort 1936 (LBC1936), and at mean ages 79, 87, 90 and 92 years in the Lothian Birth Cohort 1921 (LBC1921). We investigate whether telomere length change predicts change in cognitive and physical abilities. In LBC1936 telomere length decreased by an average of 65 base pairs per year and in LBC1921 by 69 base pairs per year. However, change in telomere length did not predict change in cognitive or physical abilities. This study shows that, although cognitive ability, walking speed, lung function and grip strength all decline with age, they do so independently of telomere length shortening.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.