ArticleNature communications2016
Periodic patterning of the Drosophila eye is stabilized by the diffusible activator Scabrous.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Patterning of theFrontiers in cell and developmental biology · 2023Review
- A neural progenitor mitotic wave is required for asynchronous axon outgrowth and morphology.eLife · 2022Article
- Article
- EyeVolve, a modular PYTHON based model for simulating developmental eye type diversification.Frontiers in cell and developmental biology · 2022Article
- Hexagonal patterning of the Drosophila eye.Developmental biology · 2021Review
- Defect patterns on the curved surface of fish retinae suggest a mechanism of cone mosaic formation.PLoS computational biology · 2020Article
- Novel approach to quantitative spatial gene expression uncovers genetic stochasticity in the developing Drosophila eye.Evolution & development · 2019Article
- The proneural wave in theeLife · 2019Article
- Threshold response to stochasticity in morphogenesis.PloS one · 2019Article
- Article
- Article
- Notch-mediated lateral inhibition regulates proneural wave propagation when combined with EGF-mediated reaction diffusion.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- A two-step patterning process increases the robustness of periodic patterning in the fly eye.Journal of biological physics · 2016Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Generation of periodic patterns is fundamental to the differentiation of multiple tissues during development. How such patterns form robustly is still unclear. The Drosophila eye comprises ∼750 units, whose crystalline order is set during differentiation of the eye imaginal disc: an activation wave sweeping across the disc is coupled to lateral inhibition, sequentially selecting pro-neural cells. Using mathematical modelling, here we show that this template-based lateral inhibition is highly sensitive to spatial variations in biochemical parameters and cell sizes. We reveal the basis of this sensitivity, and suggest that it can be overcome by assuming a short-range diffusible activator. Clonal experiments identify Scabrous, a previously implicated inhibitor, as the predicted activator. Our results reveal the mechanism by which periodic patterning in the fly eye is stabilized against spatial variations, highlighting how the need to maintain robustness shapes the design of patterning circuits.
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