Evidence map›Paper›PMID 26876477›Full record

ReviewNeuroscience letters2016

Epigenetic regulation of mitochondrial function in neurodegenerative disease: New insights from advances in genomic technologies.

Matthew Devall, Janou Roubroeks, Jonathan Mill, Michael Weedon, Katie Lunnon

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neuroscience letters, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. lncRNA Neat1 regulates neuronal dysfunction post-sepsis via stabilization of hemoglobin subunit beta.Molecular therapy : the journal of the American Society of Gene Therapy · 2022
    Article
  8. Article
  9. Mitochondrial DNA Methylation and Human Diseases.International journal of molecular sciences · 2021
    Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Mitoepigenetics and Neurodegenerative Diseases.Frontiers in endocrinology · 2019
    Review
  16. Review
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Matthew DevallInstitute of Clinical and Biomedical Science, University of Exeter Medical School, University of Exeter, Devon, UK.
Janou RoubroeksInstitute of Clinical and Biomedical Science, University of Exeter Medical School, University of Exeter, Devon, UK; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHENS), Maastricht University, Maastricht, The Netherlands.
Jonathan MillInstitute of Clinical and Biomedical Science, University of Exeter Medical School, University of Exeter, Devon, UK; Institute of Psychiatry, Psychology & Neuroscience (IoPPN), King's College London, De Crespigny Park, London, UK.
Michael WeedonInstitute of Clinical and Biomedical Science, University of Exeter Medical School, University of Exeter, Devon, UK.
Katie LunnonInstitute of Clinical and Biomedical Science, University of Exeter Medical School, University of Exeter, Devon, UK. Electronic address: k.lunnon@exeter.ac.uk.

Funding

A multi-faceted approach to epigenomic profiling in Alzheimer's disorderR01AG036039 · NIA · KING'S COLLEGE LONDON · PI MILL, JONATHAN · 2009 to 2012
$1.7M
NIA NIH HHS R01 AG036039
6 · The paper itself

Abstract

The field of mitochondrial epigenetics has received increased attention in recent years and changes in mitochondrial DNA (mtDNA) methylation has been implicated in a number of diseases, including neurodegenerative diseases such as amyotrophic lateral sclerosis. However, current publications have been limited by the use of global or targeted methods of measuring DNA methylation. In this review, we discuss current findings in mitochondrial epigenetics as well as its potential role as a regulator of mitochondria within the brain. Finally, we summarize the current technologies best suited to capturing mtDNA methylation, and how a move towards whole epigenome sequencing of mtDNA may help to advance our current understanding of the field.

Indexed as

DNA MethylationEpigenesis, GeneticAnimalsBrainDNA, MitochondrialEpigenomicsGene Expression RegulationHumansNeurodegenerative DiseasesSequence Analysis, DNADNA, MitochondrialADAlzheimer's diseaseDNA methylationEpigeneticsMitochondriamtDNA

Identifiers

PMID26876477
PMCPMC5747527

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.