ArticleVaccine2016
Risk factors for measles in children aged 8 months-14 years in China after nationwide measles campaign: A multi-site case-control study, 2012-2013.
Article in Vaccine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Epidemic risks of measles and rubella in China: a systematic review and meta-analysis.World journal of pediatrics : WJP · 2024Pooled it
- Age-stratified epidemiological and clinical predictors of laboratory-confirmed measles among suspected cases in Diyarbakır, Türkiye (2012-2024): a test-negative case-control study.BMC infectious diseases · 2026Article
- Article
- Measles outbreak investigation in Ginnir district of Bale zone, Oromia region, Southeast Ethiopia, May 2019.The Pan African medical journal · 2020Article
- Measles vaccination among children in border areas of Yunnan Province, Southwest China.PloS one · 2020Article
- Progress Toward Measles Elimination - China, January 2013-June 2019.MMWR. Morbidity and mortality weekly report · 2019Article
- Phylogenetic and Epidemiological Analysis of Measles Viruses in Shenzhen, China from January 2015 to July 2019.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Progress Toward Measles Elimination - China, January 2013-June 2019.China CDC weekly · 2019Article
- Measles Outbreak in Pediatric Hematology and Oncology Patients in Shanghai, 2015.Chinese medical journal · 2017Article
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Authors and funding
19 authors at 1 institution in 1 country.
Funding
Abstract
introductionEndemic measles persists in China, despite >95% reported coverage of two measles-containing vaccine doses and nationwide campaign that vaccinated more than 100 million children in 2010. In 2011, almost half of the 9943 measles cases in China occurred in children eligible for measles vaccination. We conducted a case-control study during 2012-2013 to identify risk factors for measles infection in children aged 8 months-14 years.
methodsChildren with laboratory-confirmed measles were age- and neighborhood-matched with three controls. We interviewed parents of case and control infants on potential risk factors for measles. We calculated adjusted matched odds ratios and 95% confidence intervals of risk factors. We calculated attributable fractions for risk factors that could be interpreted as causal and vaccine efficacy (VE) for the measles containing vaccine (MCV) used in the Chinese immunization program.
resultsIn all, 969 case-patients and 2845 controls were enrolled. In multivariable analysis, lack of measles vaccination both overall (mOR 22.7 [16.6, 31.1] and when stratified by region (east region, mOR 74.2 [27.3, 202]; central/western regions mOR 17.4 [12.5, 24.3]), hospital exposure (mOR 63.0, 95% CI [32.8, 121]), and migration among counties (overall mOR 3.0 [2.3, 3.9]) were significant risk factors. The calculated VE was 91.9-96.1% for a single dose of MCV and 96.6-99.5% for 2 doses.
conclusionsLack of vaccination was the leading risk factor for measles infection, especially in children born since the 2010 supplementary immunization activity. Reducing missed vaccination opportunities, improving immunization access for migrant children, and strengthening school/kindergarten vaccine checks are needed to strengthen the routine immunization program and maintain progress toward measles elimination in China.
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