Evidence map›Paper›PMID 26876324›Full record

ReviewThe Psychiatric clinics of North America2016

Genetics of Bipolar Disorder: Recent Update and Future Directions.

Fernando S Goes

Abstract readReview
In one paragraph

Review in The Psychiatric clinics of North America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Copy number variations in the Brazilian High-Risk Cohort for Mental Conditions.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2025
    Article
  3. Concepts of Mental Disorders Among Psychiatrists, Psychologists, and Theologians.European journal of investigation in health, psychology and education · 2024
    Article
  4. Article
  5. Review
  6. De novo variation in bipolar disorder.Molecular psychiatry · 2021
    Article
  7. Article
  8. Review
  9. Chronic Periodontitis Is Associated with the Risk of Bipolar Disorder: A Population-Based Cohort Study.International journal of environmental research and public health · 2020
    Article
  10. Review
  11. Review
  12. Twin-based heritability of actimetry traits.Genes, brain, and behavior · 2019
    Article
  13. Article
  14. International journal of bipolar disorders · 2017
    Article
  15. [Genetics of bipolar disorder].Der Nervenarzt · 2017
    Review
  16. Review
  17. Observational
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Fernando S GoesDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Meyer 4-119A, 600 North Wolfe Street, Baltimore, MD 21212, USA. Electronic address: fgoes1@jhmi.edu.

Funding

Genomewide Association & High-Throughput Sequencing of Psychotic Bipolar DisorderR00MH086049 · NIMH · JOHNS HOPKINS UNIVERSITY · PI GOES, FERNANDO SAMPAIO · 2012 to 2014
$733k
NIMH NIH HHS R00 MH086049NIMH NIH HHS R00MH86049
6 · The paper itself

Abstract

Although genetic studies of Bipolar Disorder have been pursued for decades, it has only been in the last several years that clearly replicated findings have emerged. These findings, typically of modest effects, point to a polygenic genetic architecture consisting of multiple common and rare susceptibility variants. While larger genome-wide association studies are ongoing, the advent of whole exome and genome sequencing should lead to the identification of rare, and potentially more penetrant, variants. Progress along both fronts will provide novel insights into the biology of Bipolar Disorder and help usher in a new era of personalized medicine and improved treatments.

Indexed as

Genetic Predisposition to DiseaseBipolar DisorderGenome-Wide Association StudyGenotypeHumansPhenotypeBipolar disorderCopy number variation (CNV)Family studyGeneticsGWASPersonalized medicinePharmacogeneticsSequencing

Identifiers

PMID26876324
PMCPMC7025814

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.