ArticleCell reports2016
Folate Acts in E. coli to Accelerate C. elegans Aging Independently of Bacterial Biosynthesis.
Article in Cell reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 1 synthesis or guideline pooled it, 93 citations in OpenAlex.
- A Systematic Review of Folate and the Human Enteric Microbiome: Biological Mechanisms and Clinical Implications.International journal of molecular sciences · 2026Pooled it
- Aging regulation by gut microbiota: molecular insights from Caenorhabditis elegans.Biogerontology · 2026Review
- A multi-ingredient food supplement slows age-dependent decline of mobility and influences gene expression in C. elegans.Biogerontology · 2026Article
- Iron-deplete diet enhances Caenorhabditis elegans lifespan via oxidative stress response pathways.The EMBO journal · 2025Article
- Iron-deplete diet enhancesbioRxiv : the preprint server for biology · 2025Article
- Master of Puppets: How Microbiota Drive the Nematoda Ecology and Evolution?Ecology and evolution · 2025Review
- Folate Production byJournal of microbiology and biotechnology · 2025Article
- Late-life dietary folate restriction reduces biosynthesis without compromising healthspan in mice.Life science alliance · 2024Article
- Article
- Rapid measurement of ageing by automated monitoring of movement of C. elegans populations.GeroScience · 2024Article
- Geroprotective potential of microbiome modulators in the Caenorhabditis elegans model.GeroScience · 2024Review
- Late-life dietary folate restriction reduces biosynthetic processes without compromising healthspan in mice.bioRxiv : the preprint server for biology · 2024Article
- Folate receptor overexpression induces toxicity in a diet-dependent manner in C. elegans.Scientific reports · 2024Article
- Genome-wide association and environmental suppression of the mortal germline phenotype of wild C. elegans.EMBO reports · 2023Article
- The Native Microbiome MemberMetabolites · 2023Article
- Methodology to Metabolically Inactivate Bacteria for Caenorhabditis elegans Research.Journal of visualized experiments : JoVE · 2023Article
- Neuroprotective Profile of Edible Flowers of Borage (Antioxidants (Basel, Switzerland) · 2022Article
- Alterations in Bacterial Metabolism Contribute to the Lifespan Extension Exerted by Guarana inNutrients · 2022Article
- Review
- NF-κB Regulation by Gut Microbiota Decides Homeostasis or Disease Outcome During Ageing.Frontiers in cell and developmental biology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
Abstract
Folates are cofactors for biosynthetic enzymes in all eukaryotic and prokaryotic cells. Animals cannot synthesize folate and must acquire it from their diet or microbiota. Previously, we showed that inhibiting E. coli folate synthesis increases C. elegans lifespan. Here, we show that restriction or supplementation of C. elegans folate does not influence lifespan. Thus, folate is required in E. coli to shorten worm lifespan. Bacterial proliferation in the intestine has been proposed as a mechanism for the life-shortening influence of E. coli. However, we found no correlation between C. elegans survival and bacterial growth in a screen of 1,000+ E. coli deletion mutants. Nine mutants increased worm lifespan robustly, suggesting specific gene regulation is required for the life-shortening activity of E. coli. Disrupting the biosynthetic folate cycle did not increase lifespan. Thus, folate acts through a growth-independent route in E. coli to accelerate animal aging.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.