ArticleCell reports2016
C. elegans Body Cavity Neurons Are Homeostatic Sensors that Integrate Fluctuations in Oxygen Availability and Internal Nutrient Reserves.
Article in Cell reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 43 citations in OpenAlex.
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- Quantifying Food Intake in Caenorhabditis elegans by Measuring Bacterial Clearance.Journal of visualized experiments : JoVE · 2024Article
- A single neuron inbioRxiv : the preprint server for biology · 2023Article
- Inferring a spatial code of cell-cell interactions across a whole animal body.PLoS computational biology · 2022Article
- Diverse states and stimuli tune olfactory receptor expression levels to modulate food-seeking behavior.eLife · 2022Article
- Allostasis, Action, and Affect in Depression: Insights from the Theory of Constructed Emotion.Annual review of clinical psychology · 2022Review
- Sex-specific, pdfr-1-dependent modulation of pheromone avoidance by food abundance enables flexibility in C. elegans foraging behavior.Current biology : CB · 2021Article
- Wired for insight-recent advances in Caenorhabditis elegans neural circuits.Current opinion in neurobiology · 2021Review
- Starvation Responses Throughout theGenetics · 2020Review
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- Olfactory specificity regulates lipid metabolism through neuroendocrine signaling in Caenorhabditis elegans.Nature communications · 2020Article
- Ferritin is regulated by a neuro-intestinal axis in the nematode Caenorhabditis elegans.Redox biology · 2020Article
- Intestinal peroxisomal fatty acid β-oxidation regulates neural serotonin signaling through a feedback mechanism.PLoS biology · 2019Article
- Biology of theGenetics · 2019Review
- Activity-Dependent Regulation of the Proapoptotic BH3-Only GeneG3 (Bethesda, Md.) · 2019Article
- Hypoxia Restrains Lipid Utilization via Protein Kinase A and Adipose Triglyceride Lipase Downregulation through Hypoxia-Inducible Factor.Molecular and cellular biology · 2019Article
- Article
- Oxygen-sensing neurons reciprocally regulate peripheral lipid metabolism via neuropeptide signaling in Caenorhabditis elegans.PLoS genetics · 2018Article
- Energy Scarcity Promotes a Brain-wide Sleep State Modulated by Insulin Signaling in C. elegans.Cell reports · 2018Article
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6 authors at 3 institutions in 2 countries.
Funding
Abstract
It is known that internal physiological state, or interoception, influences CNS function and behavior. However, the neurons and mechanisms that integrate sensory information with internal physiological state remain largely unknown. Here, we identify C. elegans body cavity neurons called URX(L/R) as central homeostatic sensors that integrate fluctuations in oxygen availability with internal metabolic state. We show that depletion of internal body fat reserves increases the tonic activity of URX neurons, which influences the magnitude of the evoked sensory response to oxygen. These responses are integrated via intracellular cGMP and Ca(2+). The extent of neuronal activity thus reflects the balance between the perception of oxygen and available fat reserves. The URX homeostatic sensor ensures that neural signals that stimulate fat loss are only deployed when there are sufficient fat reserves to do so. Our results uncover an interoceptive neuroendocrine axis that relays internal state information to the nervous system.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.