ArticleCell reports2016
MiR-980 Is a Memory Suppressor MicroRNA that Regulates the Autism-Susceptibility Gene A2bp1.
Article in Cell reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 45 citations in OpenAlex.
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- Inferring the genetic basis of sleep states inbioRxiv : the preprint server for biology · 2026Article
- Genetics and Molecular Biology of Memory Suppression.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2024Review
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- Post-transcriptional regulation of the transcriptional apparatus in neuronal development.Frontiers in molecular neuroscience · 2024Review
- Can RNA Affect Memory Modulation? Implications for PTSD Understanding and Treatment.International journal of molecular sciences · 2023Review
- Profiling ATM regulated genes in Drosophila at physiological condition and after ionizing radiation.Hereditas · 2022Article
- Rbfox1 is required for myofibril development and maintaining fiber type-specific isoform expression inLife science alliance · 2022Article
- MiR-33-5p Regulates CREB to Induce Morphine State-dependent Memory in Rats: Interaction with the µ Opioid Receptor.International journal of molecular and cellular medicine · 2022Article
- miRNA-Based Regulation of Alternative RNA Splicing in Metazoans.International journal of molecular sciences · 2021Review
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- A Broad-Based Mosquito Yeast Interfering RNA Pesticide TargetingPathogens (Basel, Switzerland) · 2021Article
- MicroRNA-210 Regulates Dendritic Morphology and Behavioural Flexibility in Mice.Molecular neurobiology · 2021Article
- Autism-associated miR-873 regulates ARID1B, SHANK3 and NRXN2 involved in neurodevelopment.Translational psychiatry · 2020Article
- Human genetics and neuropathology suggest a link between miR-218 and amyotrophic lateral sclerosis pathophysiology.Science translational medicine · 2019Article
- Article
- Stromalin Constrains Memory Acquisition by Developmentally Limiting Synaptic Vesicle Pool Size.Neuron · 2019Article
- TheThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- The Splicing FactorJournal of immunology (Baltimore, Md. : 1950) · 2018Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
MicroRNAs have been associated with many different biological functions, but little is known about their roles in conditioned behavior. We demonstrate that Drosophila miR-980 is a memory suppressor gene functioning in multiple regions of the adult brain. Memory acquisition and stability were both increased by miR-980 inhibition. Whole cell recordings and functional imaging experiments indicated that miR-980 regulates neuronal excitability. We identified the autism susceptibility gene, A2bp1, as an mRNA target for miR-980. A2bp1 levels varied inversely with miR-980 expression; memory performance was directly related to A2bp1 levels. In addition, A2bp1 knockdown reversed the memory gains produced by miR-980 inhibition, consistent with A2bp1 being a downstream target of miR-980 responsible for the memory phenotypes. Our results indicate that miR-980 represses A2bp1 expression to tune the excitable state of neurons, and the overall state of excitability translates to memory impairment or improvement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.