Evidence map›Paper›PMID 26875817›Full record

ArticleScientific reports2016

Optimization of a nanotechnology based antimicrobial platform for food safety applications using Engineered Water Nanostructures (EWNS).

Georgios Pyrgiotakis, Pallavi Vedantam, Caroline Cirenza, James McDevitt, Mary Eleftheriadou, Stephen S Leonard, Philip Demokritou

Abstract read
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Impact of GRAS compounds applied by ultrasonic nebulization on decay control and quality parameters in Persian lime.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Georgios PyrgiotakisCenter for Nanotechnology and Nanotoxicology, Harvard School of Public Health, Harvard University, Boston, MA, USA.
Pallavi VedantamCenter for Nanotechnology and Nanotoxicology, Harvard School of Public Health, Harvard University, Boston, MA, USA.
Caroline CirenzaCenter for Nanotechnology and Nanotoxicology, Harvard School of Public Health, Harvard University, Boston, MA, USA.
James McDevittCenter for Nanotechnology and Nanotoxicology, Harvard School of Public Health, Harvard University, Boston, MA, USA.
Mary EleftheriadouEuropean University Cyprus, The School of Sciences, Nicosia, Cyprus.
Stephen S LeonardNational Institute of Occupation Safety and Health, Morgantown, WV.
Philip DemokritouCenter for Nanotechnology and Nanotoxicology, Harvard School of Public Health, Harvard University, Boston, MA, USA.

Funding

Inactivation of ambient virues using Engineered Water NanostructuresR21AI119481 · NIAID · HARVARD SCHOOL OF PUBLIC HEALTH · PI DEMOKRITOU, PHILIP · 2015 to 2016
$438k
NIAID NIH HHS 1R21AI119481-01NIAID NIH HHS R21 AI119481
6 · The paper itself

Abstract

A chemical free, nanotechnology-based, antimicrobial platform using Engineered Water Nanostructures (EWNS) was recently developed. EWNS have high surface charge, are loaded with reactive oxygen species (ROS), and can interact-with, and inactivate an array of microorganisms, including foodborne pathogens. Here, it was demonstrated that their properties during synthesis can be fine tuned and optimized to further enhance their antimicrobial potential. A lab based EWNS platform was developed to enable fine-tuning of EWNS properties by modifying synthesis parameters. Characterization of EWNS properties (charge, size and ROS content) was performed using state-of-the art analytical methods. Further their microbial inactivation potential was evaluated with food related microorganisms such as Escherichia coli, Salmonella enterica, Listeria innocua, Mycobacterium parafortuitum, and Saccharomyces cerevisiae inoculated onto the surface of organic grape tomatoes. The results presented here indicate that EWNS properties can be fine-tuned during synthesis resulting in a multifold increase of the inactivation efficacy. More specifically, the surface charge quadrupled and the ROS content increased. Microbial removal rates were microorganism dependent and ranged between 1.0 to 3.8 logs after 45 mins of exposure to an EWNS aerosol dose of 40,000 #/cm(3).

Indexed as

NanotechnologyAnti-Infective AgentsFood MicrobiologyListeriaMicrobial ViabilityMycobacteriumNanostructuresReactive Oxygen SpeciesSaccharomyces cerevisiaeSalmonella entericaSolanum lycopersicumSurface PropertiesAnti-Infective AgentsReactive Oxygen Species

Identifiers

PMID26875817
PMCPMC4753486

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.