ArticleEuropean journal of drug metabolism and pharmacokinetics2017
Inhibitory Effects of Triptolide on Human Liver Cytochrome P450 Enzymes and P-Glycoprotein.
Article in European journal of drug metabolism and pharmacokinetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 50 citations in OpenAlex.
- Pharmacological, computational, and mechanistic insights into triptolide's role in targeting drug-resistant cancers.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Genotoxicity of pyrrolizidine alkaloids in metabolically inactive human cervical cancer HeLa cells co-cultured with human hepatoma HepG2 cells.Archives of toxicology · 2023Article
- Investigation of the effect of verapamil on the regional absorption of sofosbuvir from rabbit intestine in situ.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2022Article
- The molecular pathogenesis of triptolide-induced hepatotoxicity.Frontiers in pharmacology · 2022Review
- Article
- In vitro study on the effect of cornin on the activity of cytochrome P450 enzymes.BMC complementary medicine and therapies · 2021Article
- Succinic acid inhibits the activity of cytochrome P450 (CYP450) enzymes.Pharmaceutical biology · 2020Article
- Anemarsaponin BII inhibits the activity of CYP3A4, 2D6, and 2E1 with human liver microsomes.Pharmaceutical biology · 2020Article
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- Effects of astragaloside IV on the pharmacokinetics of omeprazole in rats.Pharmaceutical biology · 2019Article
- Article
- Effects of triptolide on pharmacokinetics of amlodipine in rats by using LC-MS/MS.Pharmaceutical biology · 2018Article
- In vitro inhibitory effects of bergenin on human liver cytochrome P450 enzymes.Pharmaceutical biology · 2018Article
- In vitro inhibitory effects of Friedelin on human liver cytochrome P450 enzymes.Pharmaceutical biology · 2018Article
- Licorice root extract and magnesium isoglycyrrhizinate protect against triptolide-induced hepatotoxicity via up-regulation of the Nrf2 pathway.Drug delivery · 2018Article
- Molecular Mechanisms Involved in Oxidative Stress-Associated Liver Injury Induced by Chinese Herbal Medicine: An Experimental Evidence-Based Literature Review and Network Pharmacology Study.International journal of molecular sciences · 2018Review
- In vitro inhibitory effects of dihydromyricetin on human liver cytochrome P450 enzymes.Pharmaceutical biology · 2017Article
- Triptolide Induces hepatotoxicity via inhibition of CYP450s in Rat liver microsomes.BMC complementary and alternative medicine · 2017Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesTriptolide is an active component derived from Tripterygium wilfordii and it possesses numerous pharmacological activities. However, it remains unclear how triptolide influences the activity of human liver cytochrome P450 (CYP) enzymes and P-glycoprotein (P-gp).
methodsIn this study, the inhibitory effects of triptolide on the eight human liver CYP isoforms (i.e., 1A2, 3A4, 2A6, 2E1, 2D6, 2C9, 2C19, and 2C8) were investigated in vitro using human liver microsomes (HLMs), and the effects of triptolide on the activity of P-gp were investigated using a rhodamine-123 uptake assay.
resultsThe results showed that triptolide inhibited the activity of CYP1A2 and CYP3A4, with 50 % inhibitory concentration (IC
conclusionsThe in vitro studies of triptolide with CYP isoforms and P-gp indicate that triptolide has the potential to cause pharmacokinetic drug interactions with other co-administered drugs metabolized by CYP1A2 and CYP3A4. Further clinical studies are needed to evaluate the significance of this interaction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.