Evidence map›Paper›PMID 26874500›Full record

ArticleThe Journal of chemical physics2016

Minimal physical requirements for crystal growth self-poisoning.

Stephen Whitelam, Yuba Raj Dahal, Jeremy D Schmit

Abstract read
In one paragraph

Article in The Journal of chemical physics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Theory of Sequence Effects in Amyloid Aggregation.The journal of physical chemistry. B · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Stephen WhitelamMolecular Foundry, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, California 94720, USA.
Yuba Raj DahalDepartment of Physics, Kansas State University, Manhattan, Kansas 66506, USA.
Jeremy D SchmitDepartment of Physics, Kansas State University, Manhattan, Kansas 66506, USA.

Funding

Theoretical and computational modeling of amyloid aggregationR01GM107487 · NIGMS · KANSAS STATE UNIVERSITY · PI SCHMIT, JEREMY DAVID · 2014 to 2018
$1.4M
NIGMS NIH HHS R01 GM107487NIGMS NIH HHS R01GM107487
6 · The paper itself

Abstract

Self-poisoning is a kinetic trap that can impair or prevent crystal growth in a wide variety of physical settings. Here we use dynamic mean-field theory and computer simulation to argue that poisoning is ubiquitous because its emergence requires only the notion that a molecule can bind in two (or more) ways to a crystal; that those ways are not energetically equivalent; and that the associated binding events occur with sufficiently unequal probability. If these conditions are met then the steady-state growth rate is in general a non-monotonic function of the thermodynamic driving force for crystal growth, which is the characteristic of poisoning. Our results also indicate that relatively small changes of system parameters could be used to induce recovery from poisoning.

Indexed as

CrystallizationThermodynamicsMolecular Dynamics Simulation

Identifiers

PMID26874500
PMCPMC4752544

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.