ArticleCerebral cortex (New York, N.Y. : 1991)2017
Subtype-Specific Genes that Characterize Subpopulations of Callosal Projection Neurons in Mouse Identify Molecularly Homologous Populations in Macaque Cortex.
Article in Cerebral cortex (New York, N.Y. : 1991), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Sequestration of growth cone surface proteins by cytoplasmic Lrrtm2 inducesbioRxiv : the preprint server for biology · 2026Article
- Cross-species single-cell transcriptomics reveals neuronal similarities and heterogeneity in amniote pallium.Zoological research · 2025Article
- Difference in axon diameter and myelin thickness between excitatory and inhibitory callosally projecting axons in mice.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- miR-409-3p repressesFrontiers in neuroscience · 2022Article
- Article
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- Transcription factor expression defines subclasses of developing projection neurons highly similar to single-cell RNA-seq subtypes.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- High Angular Resolution Diffusion MRI Reveals Conserved and Deviant Programs in the Paths that Guide Human Cortical Circuitry.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Transient callosal projections of L4 neurons are eliminated for the acquisition of local connectivity.Nature communications · 2019Article
- The Structural Model: a theory linking connections, plasticity, pathology, development and evolution of the cerebral cortex.Brain structure & function · 2019Review
- Molecular anatomy of the alligator dorsal telencephalon.The Journal of comparative neurology · 2018Article
- Specialized Subpopulations of Deep-Layer Pyramidal Neurons in the Neocortex: Bridging Cellular Properties to Functional Consequences.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Review
- Callosal responses in a retrosplenial column.Brain structure & function · 2018Article
- Transcription factor programming of human ES cells generates functional neurons expressing both upper and deep layer cortical markers.PloS one · 2018Article
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Callosal projection neurons (CPN) interconnect the neocortical hemispheres via the corpus callosum and are implicated in associative integration of multimodal information. CPN have undergone differential evolutionary elaboration, leading to increased diversity of cortical neurons-and more extensive and varied connections in neocortical gray and white matter-in primates compared with rodents. In mouse, distinct sets of genes are enriched in discrete subpopulations of CPN, indicating the molecular diversity of rodent CPN. Elements of rodent CPN functional and organizational diversity might thus be present in the further elaborated primate cortex. We address the hypothesis that genes controlling mouse CPN subtype diversity might reflect molecular patterns shared among mammals that arose prior to the divergence of rodents and primates. We find that, while early expression of the examined CPN-enriched genes, and postmigratory expression of these CPN-enriched genes in deep layers are highly conserved (e.g., Ptn, Nnmt, Cited2, Dkk3), in contrast, the examined genes expressed by superficial layer CPN show more variable levels of conservation (e.g., EphA3, Chn2). These results suggest that there has been evolutionarily differential retraction and elaboration of superficial layer CPN subpopulations between mouse and macaque, with independent derivation of novel populations in primates. Together, these data inform future studies regarding CPN subpopulations that are unique to primates and rodents, and indicate putative evolutionary relationships.
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