Evidence map›Paper›PMID 26873887›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2017

Stimulation of astrocyte fatty acid oxidation by thyroid hormone is protective against ischemic stroke-induced damage.

Naomi L Sayre, Mikaela Sifuentes, Deborah Holstein, Sheue-Yann Cheng, Xuguang Zhu, James D Lechleiter

Open access · bronzeAbstract read
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Observational
  4. Review
  5. Article
  6. Article
  7. The role of astrocyte metabolic reprogramming in ischemic stroke (Review).International journal of molecular medicine · 2025
    Review
  8. Article
  9. HADHA Regulates Respiratory Complex Assembly and Couples FAO and OXPHOS.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  10. Article
  11. Fatty acid preference for beta-oxidation in mitochondria of murine cultured astrocytes.Genes to cells : devoted to molecular & cellular mechanisms · 2024
    Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Review
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Naomi L Sayre1 Department of Neurosurgery, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Mikaela Sifuentes2 Department of Cellular & Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Deborah Holstein2 Department of Cellular & Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Sheue-Yann Cheng3 Gene Regulation Section, Laboratory of Molecular Biology, National Institutes of Health, Bethesda, MD, 20892.
Xuguang Zhu3 Gene Regulation Section, Laboratory of Molecular Biology, National Institutes of Health, Bethesda, MD, 20892.
James D Lechleiter2 Department of Cellular & Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
The University of Texas Health Science Center at San Antonio · USNational Institutes of Health · US

Funding

Thyroid Hormone Receptors in Health and DiseaseZIABC008752 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI CHENG, SHEUE-YANN · 2009 to 2025
$12.9M
6 · The paper itself

Abstract

We previously demonstrated that stimulation of astrocyte mitochondrial ATP production via P2Y

Indexed as

Adenosine TriphosphateAnimalsAstrocytesBrain IschemiaCells, CulturedCell SurvivalFatty AcidsFemaleGlial Fibrillary Acidic ProteinHippocampusHumansMiceMice, Inbred C57BLMitochondrial Trifunctional Protein, alpha SubunitNeuroprotectionNeuroprotective AgentsAdenosine TriphosphateFatty AcidsGlial Fibrillary Acidic ProteinHadha protein, mouseMitochondrial Trifunctional Protein, alpha SubunitNeuroprotective AgentsTriiodothyronineAstrocytefatty acid oxidationneuroprotectionstrokethyroid hormone

Identifiers

PMID26873887
PMCPMC5381439
OpenAlexW2266012132

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.