Evidence map›Paper›PMID 26873754›Full record

ArticleCerebellum (London, England)2017

Consensus Paper: Towards a Systems-Level View of Cerebellar Function: the Interplay Between Cerebellum, Basal Ganglia, and Cortex.

Daniele Caligiore, Giovanni Pezzulo, Gianluca Baldassarre, Andreea C Bostan, Peter L Strick, Kenji Doya, Rick C Helmich, Michiel Dirkx, James Houk, Henrik Jörntell and 8 more

Abstract readConsensus Statement
In one paragraph

Article in Cerebellum (London, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 218 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
218citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

218 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
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  11. Distinct Brain Drivers and Shared Cerebello-Cortical Input in ADCY5 and SGCE Hyperkinetic Movements.Movement disorders : official journal of the Movement Disorder Society · 2026
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158 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Daniele CaligioreIstituto di Scienze e Tecnologie della Cognizione, Consiglio Nazionale delle Ricerche (ISTC-CNR), Via San Martino della Battaglia 44, 00185, Rome, Italy. daniele.caligiore@istc.cnr.it.
Giovanni PezzuloIstituto di Scienze e Tecnologie della Cognizione, Consiglio Nazionale delle Ricerche (ISTC-CNR), Via San Martino della Battaglia 44, 00185, Rome, Italy.
Gianluca BaldassarreIstituto di Scienze e Tecnologie della Cognizione, Consiglio Nazionale delle Ricerche (ISTC-CNR), Via San Martino della Battaglia 44, 00185, Rome, Italy.
Andreea C BostanSystems Neuroscience Institute, Department of Neurobiology, and Center for the Neural Basis of Cognition, University of Pittsburgh, 3501 Fifth Avenue, 4079 BST-3, Pittsburgh, PA, 15261, USA.
Peter L StrickSystems Neuroscience Institute, Department of Neurobiology, and Center for the Neural Basis of Cognition, University of Pittsburgh, 3501 Fifth Avenue, 4079 BST-3, Pittsburgh, PA, 15261, USA.
Kenji DoyaNeural Computation Unit, Okinawa Institute of Science and Technology, 1919-1 Tancha, Onna-son, Kunigami-gun, Okinawa, 904-0495, Japan.
Rick C HelmichDepartment of Neurology, Radboud University Nijmegen Medical Center (HP 935), PO Box 9101, 6500 HB, Nijmegen, The Netherlands.
Michiel DirkxDepartment of Neurology, Radboud University Nijmegen Medical Center (HP 935), PO Box 9101, 6500 HB, Nijmegen, The Netherlands.
James HoukDepartment of Physiology, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue M211, Chicago, IL, 60611, USA.
Henrik JörntellNeural Basis of Sensorimotor Control, Department of Experimental Medical Science, Lund University, BMC F10 Tornavägen 10, 221 84, Lund, Sweden.
Angel Lago-RodriguezSchool of Psychology, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
Joseph M GaleaSchool of Psychology, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
R Chris MiallSchool of Psychology, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
Traian PopaHuman Motor Control Section, National Institute of Neurological Diseases and Stroke (NINDS), National Institutes of Health (NIH), Bethesda, MD, 20982, USA.
Asha KishoreComprehensive Care Centre for Movement Disorders, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Kerala, 695011, India.
Paul F M J VerschureDepartment of Information and Communication Technologies, Universitat Pompeu Fabra, Barcelona, Spain.
Riccardo ZuccaDepartment of Information and Communication Technologies, Universitat Pompeu Fabra, Barcelona, Spain.
Ivan HerrerosDepartment of Information and Communication Technologies, Universitat Pompeu Fabra, Barcelona, Spain.

Funding

ResourceP40OD010996 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STRICK, PETER · 2012 to 2024
$11.0M
PREMOTOR AREAS IN THE FRONTAL LOBER01NS024328 · NINDS · UPSTATE MEDICAL UNIVERSITY · PI STRICK, PETER · 1987 to 2015
$8.9M
BASAL GANGLIA, CEREBELLUM AND HIGHER CORTICAL FUNCTIONR01MH056661 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STRICK, PETER · 1997 to 2012
$4.0M
Surgery Core - NINDS Institutional Core Grants to Support Neuroscience ResearchP30NS076405 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STRICK, PETER · 2012 to 2016
$1.8M
Medical Research Council MR/J012610/1NIH HHS P40 OD010996NIMH NIH HHS R01 MH056661NINDS NIH HHS P30 NS076405NINDS NIH HHS R01 NS024328Wellcome Trust WT087554
6 · The paper itself

Abstract

Despite increasing evidence suggesting the cerebellum works in concert with the cortex and basal ganglia, the nature of the reciprocal interactions between these three brain regions remains unclear. This consensus paper gathers diverse recent views on a variety of important roles played by the cerebellum within the cerebello-basal ganglia-thalamo-cortical system across a range of motor and cognitive functions. The paper includes theoretical and empirical contributions, which cover the following topics: recent evidence supporting the dynamical interplay between cerebellum, basal ganglia, and cortical areas in humans and other animals; theoretical neuroscience perspectives and empirical evidence on the reciprocal influences between cerebellum, basal ganglia, and cortex in learning and control processes; and data suggesting possible roles of the cerebellum in basal ganglia movement disorders. Although starting from different backgrounds and dealing with different topics, all the contributors agree that viewing the cerebellum, basal ganglia, and cortex as an integrated system enables us to understand the function of these areas in radically different ways. In addition, there is unanimous consensus between the authors that future experimental and computational work is needed to understand the function of cerebellar-basal ganglia circuitry in both motor and non-motor functions. The paper reports the most advanced perspectives on the role of the cerebellum within the cerebello-basal ganglia-thalamo-cortical system and illustrates other elements of consensus as well as disagreements and open questions in the field.

Indexed as

AnimalsBasal GangliaCerebellumCerebral CortexHumansNeural PathwaysBasal ganglia cerebellum anatomical linkCerebellar motor and cognitive functionMovement disordersNon-invasive brain stimulationNucleo-olivary inhibitionParkinson’s disease tremor

Identifiers

PMID26873754
PMCPMC5243918

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.