Evidence map›Paper›PMID 26873724›Full record

ArticleJournal of the American Society for Mass Spectrometry2016

Rapid Detection of Ricin in Serum Based on Cu-Chelated Magnetic Beads Using Mass Spectrometry.

Yong-Qiang Zhao, Jian Song, Hong-Li Wang, Bin Xu, Feng Liu, Kun He, Na Wang

Abstract readEvaluation Study
PubMed Publisher
In one paragraph

Article in Journal of the American Society for Mass Spectrometry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Yong-Qiang ZhaoThe Institute of Basic Medical Sciences, National Center of Biomedical Analysis, Beijing, China, 100850.
Jian SongThe School of Pharmacy, Jilin University, Changchun, China, 130021.
Hong-Li WangThe Institute of Basic Medical Sciences, National Center of Biomedical Analysis, Beijing, China, 100850.
Bin XuThe Institute of Basic Medical Sciences, National Center of Biomedical Analysis, Beijing, China, 100850.
Feng LiuThe Institute of Basic Medical Sciences, National Center of Biomedical Analysis, Beijing, China, 100850.
Kun HeThe Institute of Basic Medical Sciences, National Center of Biomedical Analysis, Beijing, China, 100850. hk@proteomics.cn.
Na WangThe Institute of Basic Medical Sciences, National Center of Biomedical Analysis, Beijing, China, 100850. nwang@ncba.ac.cn.
National Center of Biomedical Analysis · CNJilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The protein toxin ricin obtained from castor bean plant (Ricinus communis) seeds is a potent biological warfare agent due to its ease of availability and acute toxicity. In this study, we demonstrated a rapid and simple method to detect ricin in serum in vitro. The ricin was mixed with serum and digested by trypsin, then all the peptides were efficiently extracted using Cu-chelated magnetic beads and were detected with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. The specific ricin peptides were identified by Nanoscale Ultra Performance liquid chromatography coupled to tandem mass spectrometry according to their sequences. The assay required 2.5 hours, and a characteristic peptide could be detected down to 4 ng/μl and used as a biomarker to detect ricin in serum. The high sensitivity and simplicity of the procedure makes it valuable in clinical practice. Graphical Abstract ᅟ.

Indexed as

Amino Acid SequenceChelating AgentsChemical Warfare AgentsChromatography, High Pressure LiquidCopperHumansLimit of DetectionMagnetsReproducibility of ResultsRicinRicinusSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationChelating AgentsChemical Warfare AgentsCopperRicinCu-MagbeadsMass spectrometryRapid detectionRicin

Identifiers

PMID26873724
OpenAlexW2252976293

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.