ArticleGenome medicine2016
Identifying the effect of patient sharing on between-hospital genetic differentiation of methicillin-resistant Staphylococcus aureus.
Article in Genome medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed.
- Reconstructing healthcare networks from patient transfer data: A systematic review.PLOS digital health · 2026Article
- Threshold-free genomic cluster detection to track transmission pathways in health-care settings: a genomic epidemiology analysis.The Lancet. Microbe · 2022Article
- Widespread sharing of pneumococcal strains in a rural African setting: proximate villages are more likely to share similar strains that are carried at multiple timepoints.Microbial genomics · 2022Article
- Article
- Mapping malaria by combining parasite genomic and epidemiologic data.BMC medicine · 2018Article
- Frequent Undetected Ward-Based Methicillin-Resistant Staphylococcus aureus Transmission Linked to Patient Sharing Between Hospitals.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Observational
- Article
- Population genetic structuring of methicillin-resistantMicrobial genomics · 2017Article
- Genomic and Epidemiological Evidence for Community Origins of Hospital-Onset Methicillin-Resistant Staphylococcus aureus Bloodstream Infections.The Journal of infectious diseases · 2017Article
- The relative importance of large problems far away versus small problems closer to home: insights into limiting the spread of antimicrobial resistance in England.BMC medicine · 2017Article
- Whole Genome Sequencing-Implications for Infection Prevention and Outbreak Investigations.Current infectious disease reports · 2017Review
- The Promise of Whole Genome Pathogen Sequencing for the Molecular Epidemiology of Emerging Aquaculture Pathogens.Frontiers in microbiology · 2017Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundMethicillin-resistant Staphylococcus aureus (MRSA) is one of the most common healthcare-associated pathogens. To examine the role of inter-hospital patient sharing on MRSA transmission, a previous study collected 2,214 samples from 30 hospitals in Orange County, California and showed by spa typing that genetic differentiation decreased significantly with increased patient sharing. In the current study, we focused on the 986 samples with spa type t008 from the same population.
methodsWe used genome sequencing to determine the effect of patient sharing on genetic differentiation between hospitals. Genetic differentiation was measured by between-hospital genetic diversity, F ST , and the proportion of nearly identical isolates between hospitals.
resultsSurprisingly, we found very similar genetic diversity within and between hospitals, and no significant association between patient sharing and genetic differentiation measured by F ST . However, in contrast to F ST , there was a significant association between patient sharing and the proportion of nearly identical isolates between hospitals. We propose that the proportion of nearly identical isolates is more powerful at determining transmission dynamics than traditional estimators of genetic differentiation (F ST ) when gene flow between populations is high, since it is more responsive to recent transmission events. Our hypothesis was supported by the results from coalescent simulations.
conclusionsOur results suggested that there was a high level of gene flow between hospitals facilitated by patient sharing, and that the proportion of nearly identical isolates is more sensitive to population structure than F ST when gene flow is high.
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