Evidence map›Paper›PMID 26873700›Full record

ArticleMalaria journal2016

Fake anti-malarials: start with the facts.

Harparkash Kaur, Siȃn Clarke, Mirza Lalani, Souly Phanouvong, Philippe Guérin, Andrew McLoughlin, Benjamin K Wilson, Michael Deats, Aline Plançon, Heidi Hopkins and 2 more

Abstract read
In one paragraph

Article in Malaria journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Article
  6. Article
  7. Article
  8. Quality of Essential Medicines from Different Sources in Enugu and Anambra, Nigeria.The American journal of tropical medicine and hygiene · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. "Global bioethics = Problemi di bioetica · 2022
    Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Substandard, falsified and unregistered medicines in Latin America, 2017-2018.Revista panamericana de salud publica = Pan American journal of public health · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Harparkash KaurLondon School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK. Harparkash.kaur@lshtm.ac.uk.
Siȃn ClarkeLondon School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK. Sian.Clarke@lshtm.ac.uk.
Mirza LalaniLondon School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK. mirza.lalani@lshtm.ac.uk.
Souly PhanouvongPromoting the Quality of Medicines Program, U.S. Pharmacopeial Convention, Rockville, MD, USA. sxp@usp.org.
Philippe GuérinWorldwide Antimalarial Resistance Network (WWARN), University of Oxford, Oxford, UK. Philippe.Guerin@wwarn.org.
Andrew McLoughlinThe Global Fund to Fight Aids, Tuberculosis and Malaria, Geneva, Switzerland. Andrew.McLoughlin@theglobalfund.org.
Benjamin K WilsonIntellectual Ventures Laboratory, Bellevue, WA, USA. bwilson@intven.com.
Michael DeatsSSFFC Surveillance and Monitoring, Safety and Vigilance, Essential Medicines and Health Products, World Health Organization, Geneva, Switzerland. deatsm@who.int.
Aline PlançonMedical Product Counterfeiting and Pharmaceutical Crime Sub-Directorate, INTERPOL, Lyon, France. a.plancon@interpol.int.
Heidi HopkinsLondon School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK. Heidi.Hopkins@lshtm.ac.uk.
Debora MirandaLondon School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK. Debora.Miranda@lshtm.ac.uk.
David SchellenbergLondon School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK. David.Schellenberg@lshtm.ac.uk.

Funding

World Health Organization 001
6 · The paper itself

Abstract

This meeting report presents the key findings and discussion points of a 1-day meeting entitled 'Fake anti-malarials: start with the facts' held on 28th May 2015, in Geneva, Switzerland, to disseminate the findings of the artemisinin combination therapy consortium's drug quality programme. The teams purchased over 10,000 samples, using representative sampling approaches, from six malaria endemic countries: Equatorial Guinea (Bioko Island), Cambodia, Ghana, Nigeria, Rwanda and Tanzania. Laboratory analyses of these samples showed that falsified anti-malarials (<8 %) were found in just two of the countries, whilst substandard artemisinin-based combinations were present in all six countries and, artemisinin-based monotherapy tablets are still available in some places despite the fact that the WHO has urged regulatory authorities in malaria-endemic countries to take measures to halt the production and marketing of these oral monotherapies since 2007. This report summarizes the presentations that reviewed the public health impact of falsified and substandard drugs, sampling strategies, techniques for drug quality analysis, approaches to strengthen health systems capacity for the surveillance of drug quality, and the ensuing discussion points from the dissemination meeting.

Indexed as

AntimalarialsArtemisininsDrug Therapy, CombinationHumansMalariaAntimalarialsArtemisinins

Identifiers

PMID26873700
PMCPMC4752758

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.