Trial reportInvestigative ophthalmology & visual science2016
Between-Subject Variability in Healthy Eyes as a Primary Source of Structural-Functional Discordance in Patients With Glaucoma.
Trial report in Investigative ophthalmology & visual science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Using perimetric data to estimate ganglion cell loss for detecting progression of glaucoma: a comparison of models.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2017Trial
- Predicting HFA 30-2 Visual Fields with Deep Learning from Multimodal OCT-Fundus Feature Fusion and Structure-Function Discordance Analysis.Journal of imaging informatics in medicine · 2026Article
- Cumulative Loss of Inner Retinal Neurons in Healthy and Glaucoma Subjects.Investigative ophthalmology & visual science · 2026Article
- Targeted perimetry for mapping the shape of glaucomatous arcuate scotomata.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2025Article
- Using high-density perimetry to explore new approaches for characterizing visual field defects.Vision research · 2023Article
- High sampling resolution optical coherence tomography reveals potential concurrent reductions in ganglion cell-inner plexiform and inner nuclear layer thickness but not in outer retinal thickness in glaucoma.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2023Article
- Structure-Function Mapping Using a Three-Dimensional Neuroretinal Rim Parameter Derived From Spectral Domain Optical Coherence Tomography Volume Scans.Translational vision science & technology · 2021Article
- Structural and Functional Abnormalities in Early-stage Diabetic Retinopathy.Current eye research · 2020Article
- Assessing the Impact of En Face Retinal Nerve Fiber Layer Imaging on Clinical Decision Making for Glaucoma Suspects.Optometry and vision science : official publication of the American Academy of Optometry · 2020Article
- A novel Bayesian adaptive method for mapping the visual field.Journal of vision · 2019Article
- Longitudinal Macular Structure-Function Relationships in Glaucoma and Their Sources of Variability.American journal of ophthalmology · 2019Article
- Using Small Samples to Evaluate Normative Reference Ranges for Retinal Imaging Measures.Optometry and vision science : official publication of the American Academy of Optometry · 2019Article
- Article
- Comparison of defect depths for sinusoidal and circular perimetric stimuli in patients with glaucoma.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2019Article
- Customizing Perimetric Locations Based on En Face Images of Retinal Nerve Fiber Bundles With Glaucomatous Damage.Translational vision science & technology · 2018Article
- Association of Glaucoma-Related, Optical Coherence Tomography-Measured Macular Damage With Vision-Related Quality of Life.JAMA ophthalmology · 2017Article
- Localized Changes in Retinal Nerve Fiber Layer Thickness as a Predictor of Localized Functional Change in Glaucoma.American journal of ophthalmology · 2016Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
purposeTo test with an independent data set the finding that between-subject variability in healthy eyes is the primary source of structural-functional discordance in patients with glaucoma.
methodsNeuroretinal rim area, retinal nerve fiber layer thickness, and perimetric data were analyzed for one eye in each of 55 control subjects and for 245 right eyes of patients in the United Kingdom Glaucoma Treatment Study. Data were gathered with the Heidelberg Retina Tomograph (HRT), Stratus Optical Coherence Tomograph (OCT), and Humphrey Field Analyzer (HFA). Discordance was quantified as width of the limits of agreement from a Bland-Altman analysis of depth of defect. The ratio of variances (F test) for the patient and control groups was computed for comparisons of HFA-OCT, HFA-HRT, and OCT-HRT. Bonferroni adjustment required P less than 0.017 for statistical significance. The discordance in the patients was also quantified as the 95% prediction interval computed from the discordance in controls using the Hood-Kardon model for the HFA-OCT comparison.
resultsThe F ratio comparing discordance in patients and controls was 0.77, 1.43, and 1.32 for the HFA-OCT, HFA-HRT, and OCT-HRT comparisons with P values 0.88, 0.06, and 0.11, respectively. For the Hood-Kardon model, 4.7% of the patients had discordance outside the 95% prediction interval computed from the discordance in controls. Similar results were obtained when all comparisons were repeated for left eyes of patients.
conclusionsThese results confirm previous findings that between-subject variability in healthy eyes is the primary source of structural-functional discordance in patients with glaucoma, and extends this finding to a structural-structural comparison.
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