Evidence map›Paper›PMID 26873444›Full record

ArticleJournal of translational medicine2016

First translational 'Think Tank' on cerebrovascular disease, cognitive impairment and dementia.

Frank C Barone, Deborah Gustafson, Howard A Crystal, Herman Moreno, Mateusz G Adamski, Ken Arai, Alison E Baird, Clotilde Balucani, Adam M Brickman, David Cechetto and 9 more

Open access · goldAbstract readConference Proceedings
In one paragraph

Article in Journal of translational medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Carotid disease at age 73 and cognitive change from age 70 to 76 years: A longitudinal cohort study.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 14 institutions in 4 countries.

Frank C BaroneNeurology, SUNY Downstate Medical Center, Brooklyn, NY, USA. frank.barone@downstate.edu.
Deborah GustafsonNeurology, SUNY Downstate Medical Center, Brooklyn, NY, USA. deborah.gustafson@downstate.edu.
Howard A CrystalNeurology, SUNY Downstate Medical Center, Brooklyn, NY, USA. howard.crystal@downstate.edu.
Herman MorenoNeurology, SUNY Downstate Medical Center, Brooklyn, NY, USA. herman.moreno@downstate.edu.
Mateusz G AdamskiJagiellonian Centre for Experimental Therapeutics, Jagiellonian University, Krakow, Poland. adamskimateusz@yahoo.com.
Ken AraiNeuroprotection Research Laboratory, Departments of Radiology and Neurology, Massachusetts General Hospital, Harvard Medical School, CharlesTown, Boston, MA, USA. karai@mgh.harvard.edu.
Alison E BairdNeurology, SUNY Downstate Medical Center, Brooklyn, NY, USA. alison.baird@Downstate.edu.
Clotilde BalucaniNeurology, SUNY Downstate Medical Center, Brooklyn, NY, USA. clotilde.balucani@downstate.edu.
Adam M BrickmanTaub Institute for Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA. amb2139@cumc.columbia.edu.
David CechettoDepartment of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada. cechetto@uwo.ca.
Philip GorelickTranslational Science and Molecular Medicine, Michigan State University College of Human Medicine, Mercy Health Hauenstein Neurosciences, Grand Rapids, MI, USA. pgorelic@trinity-health.org.
Geert Jan BiesselsDepartment of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands. g.j.biessels@umcutrecht.nl.
Amanda KiliaanDepartment of Anatomy, Preclinical Imaging Center, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center Nijmegen, Nijmegen, The Netherlands. Amanda.kiliaan@radboudumc.nl.
Lenore LaunerNeuroepidemiology Section, Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA. launerl@nia.nih.gov.
Julie SchneiderPathology (Neuropathology) and Neurological Sciences, Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA. Julie_A_Schneider@rush.edu.
Farzaneh A SorondDepartment of Neurology, Stroke Division, Brigham and Women's Hospital, Boston, MA, USA. fsorond@partners.org.
Rachel WhitmerDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA. rachel.whitmer@kp.org.
Clinton WrightMcKnight Brain Institute, Division of Cognitive Disorders, Neurology, Public Health Sciences and Neuroscience, University of Miami, Miami, FL, USA. CWright@med.miami.edu.
Zheng Gang ZhangNeurology, Henry Ford Hospital, Detroit, MI, USA. zhazh@neuro.hfh.edu.
SUNY Downstate Health Sciences University · USBrigham and Women's Hospital · USColumbia University Irving Medical Center · USHarvard University · USHenry Ford Hospital · USJagiellonian University · PLKaiser Permanente · USNational Institutes of Health · USRadboud University Nijmegen · NLRush University Medical Center · USTrinity Health Grand Rapids · USUniversity Medical Center Utrecht · NLUniversity of Miami · USWestern University · CA

Funding

Cerebral Small Vessels in Motor and Cognitive Decline: Neuroimaging Signatures of Vulnerability & ResilienceR01NS085002 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI FARZANEH A SOROND · 2014 to 2026
$3.8M
Oligo-Vascular Signaling in StrokeR01NS065089 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI ARAI, KEN · 2010 to 2019
$3.8M
Effects of Vascular Health, Aging, and HAART on Cognition in HIV: A Pilot StudyR21MH097639 · NIMH · SUNY DOWNSTATE MEDICAL CENTER · PI CRYSTAL, HOWARD A · 2012 to 2013
$455k
NIMH NIH HHS R21 MH097639NINDS NIH HHS R01 NS065089NINDS NIH HHS R01 NS085002
6 · The paper itself

Abstract

As the human population continues to age, an increasing number of people will exhibit significant deficits in cognitive function and dementia. It is now recognized that cerebrovascular, metabolic and neurodegenerative diseases all play major roles in the evolution of cognitive impairment and dementia. Thus with our more recent recognition of these relationships and our need to understand and more positively impact on this world health problem, "The Leo and Anne Albert Charitable Trust" (Gene Pranzo, Trustee with significant support from Susan Brogan, Meeting Planner) provided generous support for this inaugural international workshop that was held from April 13-16, 2015 at the beautiful Ritz Carlton Golf Resort in North Naples, Florida. Researchers from SUNY Downstate Medical Center, Brooklyn, NY organized the event by selecting the present group of translationally inclined preclinical, clinical and population scientists focused on cerebrovascular disease (CVD) risk and its progression to vascular cognitive impairment (VCI) and dementia. Participants at the workshop addressed important issues related to aging, cognition and dementia by: (1) sharing new data, information and perspectives that intersect vascular, metabolic and neurodegenerative diseases, (2) discussing gaps in translating population risk, clinical and preclinical information to the progression of cognitive loss, and (3) debating new approaches and methods to fill these gaps that can translate into future therapeutic interventions. Participants agreed on topics for group discussion prior to the meeting and focused on specific translational goals that included promoting better understanding of dementia mechanisms, the identification of potential therapeutic targets for intervention, and discussed/debated the potential utility of diagnostic/prognostic markers. Below summarizes the new data-presentations, concepts, novel directions and specific discussion topics addressed by this international translational team at our "First Leo and Anne Albert Charitable Trust 'Think Tank' VCI workshop".

Indexed as

Translational Research, BiomedicalAnimalsBiomarkersCerebrovascular DisordersCognition DisordersDementiaDisease Models, AnimalHumansMiceRatsBiomarkers

Identifiers

PMID26873444
PMCPMC4752794
OpenAlexW2260428157

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.