ArticleApplied and environmental microbiology2016
Activities of Secreted Aryl Alcohol Quinone Oxidoreductases from Pycnoporus cinnabarinus Provide Insights into Fungal Degradation of Plant Biomass.
Article in Applied and environmental microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 66 citations in OpenAlex.
- Aryl-alcohol oxidases: catalysis, diversity, structure-function and emerging biotechnological applications.Applied microbiology and biotechnology · 2025Review
- Metal-Triggered FAD Reduction in d-2-Hydroxyglutarate Dehydrogenase fromACS bio & med chem Au · 2025Article
- Substrate specificity mapping of fungal CAZy AA3_2 oxidoreductases.Biotechnology for biofuels and bioproducts · 2024Article
- Unveiling the kinetic versatility of aryl-alcohol oxidases with different electron acceptors.Frontiers in bioengineering and biotechnology · 2024Article
- Transcriptomics of Temporal- versus Substrate-Specific Wood Decay in the Brown-Rot FungusJournal of fungi (Basel, Switzerland) · 2023Article
- Expanding the Physiological Role of Aryl-Alcohol Flavooxidases as Quinone Reductases.Applied and environmental microbiology · 2023Article
- Whole genome sequencing and analysis of Armillaria gallica Jzi34 symbiotic with Gastrodia elata.BMC genomics · 2023Article
- In Vitro Fermentation of Beechwood Lignin-Carbohydrate Complexes Provides Evidence for Utilization by Gut Bacteria.Nutrients · 2023Article
- Characterization of a novel AA3_1 xylooligosaccharide dehydrogenase from Thermothelomyces myriococcoides CBS 398.93.Biotechnology for biofuels and bioproducts · 2022Article
- A Putative Lignin Copper Oxidase fromJournal of fungi (Basel, Switzerland) · 2021Article
- Genome and Secretome Analysis ofMicroorganisms · 2021Article
- Crystal structure and functional characterization of an oligosaccharide dehydrogenase from Pycnoporus cinnabarinus provides insights into fungal breakdown of lignocellulose.Biotechnology for biofuels · 2021Article
- Pecularities and applications of aryl-alcohol oxidases from fungi.Applied microbiology and biotechnology · 2021Review
- Evolution of Fungal Carbohydrate-Active Enzyme Portfolios and Adaptation to Plant Cell-Wall Polymers.Journal of fungi (Basel, Switzerland) · 2021Review
- Characterization of the CAZy Repertoire from the Marine-Derived FungusMarine drugs · 2020Article
- iTRAQ-based proteomic analysis reveals the mechanisms of Botrytis cinerea controlled with Wuyiencin.BMC microbiology · 2019Article
- The GMC superfamily of oxidoreductases revisited: analysis and evolution of fungal GMC oxidoreductases.Biotechnology for biofuels · 2019Article
- Oxidoreductases and Reactive Oxygen Species in Conversion of Lignocellulosic Biomass.Microbiology and molecular biology reviews : MMBR · 2018Review
- Multiplicity of enzymatic functions in the CAZy AA3 family.Applied microbiology and biotechnology · 2018Review
- Integrative visual omics of the white-rot fungusBiotechnology for biofuels · 2018Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Auxiliary activities family 3 subfamily 2 (AA3_2) from the CAZy database comprises various functions related to ligninolytic enzymes, such as fungal aryl alcohol oxidases (AAO) and glucose oxidases, both of which are flavoenzymes. The recent study of the Pycnoporus cinnabarinus CIRM BRFM 137 genome combined with its secretome revealed that four AA3_2 enzymes are secreted during biomass degradation. One of these AA3_2 enzymes, scf184803.g17, has recently been produced heterologously in Aspergillus niger Based on the enzyme's activity and specificity, it was assigned to the glucose dehydrogenases (PcinnabarinusGDH [PcGDH]). Here, we analyze the distribution of the other three AA3_2 enzymes (scf185002.g8, scf184611.g7, and scf184746.g13) to assess their putative functions. These proteins showed the highest homology with aryl alcohol oxidase from Pleurotus eryngii Biochemical characterization demonstrated that they were also flavoenzymes harboring flavin adenine dinucleotide (FAD) as a cofactor and able to oxidize a wide variety of phenolic and nonphenolic aryl alcohols and one aliphatic polyunsaturated primary alcohol. Though presenting homology with fungal AAOs, these enzymes exhibited greater efficiency in reducing electron acceptors (quinones and one artificial acceptor) than molecular oxygen and so were defined as aryl-alcohol:quinone oxidoreductases (AAQOs) with two enzymes possessing residual oxidase activity (PcAAQO2 and PcAAQO3). Structural comparison of PcAAQO homology models with P. eryngii AAO demonstrated a wider substrate access channel connecting the active-site cavity to the solvent, explaining the absence of activity with molecular oxygen. Finally, the ability of PcAAQOs to reduce radical intermediates generated by laccase from P. cinnabarinus was demonstrated, shedding light on the ligninolytic system of this fungus.
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