ArticleAnalytical and bioanalytical chemistry2016
Rapid evaluation of artesunate quality with a specific monoclonal antibody-based lateral flow dipstick.
Article in Analytical and bioanalytical chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 14 citations in OpenAlex.
- Preparation and application of a specific single-chain variable fragment against artemether.Journal of pharmaceutical and biomedical analysis · 2022Article
- Malaria Research for Tailored Control and Elimination Strategies in the Greater Mekong Subregion.The American journal of tropical medicine and hygiene · 2022Article
- Development of single- and multiplex immunoassays for rapid detection and quantitation of amodiaquine in ACT drugs and rat serum.Analytical and bioanalytical chemistry · 2022Article
- Development and application of immunoassays for rapid quality control of the antimalarial drug combination artesunate-mefloquine.Journal of pharmaceutical and biomedical analysis · 2022Article
- Laboratory evaluation of twelve portable devices for medicine quality screening.PLoS neglected tropical diseases · 2021Article
- Rapid quantification of artemisinin derivatives in antimalarial drugs with dipstick immunoassays.Journal of pharmaceutical and biomedical analysis · 2020Article
- Development of monoclonal antibody-based immunoassays for quantification and rapid assessment of dihydroartemisinin contents in antimalarial drugs.Journal of pharmaceutical and biomedical analysis · 2018Article
- Field detection devices for screening the quality of medicines: a systematic review.BMJ global health · 2018Article
- Quality Testing of Artemisinin-Based Antimalarial Drugs in Myanmar.The American journal of tropical medicine and hygiene · 2017Article
- Article
- Pilot testing of dipsticks as point-of-care assays for rapid diagnosis of poor-quality artemisinin drugs in endemic settings.Tropical medicine and health · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
Abstract
Artesunate is a frontline antimalarial drug for treating Plasmodium falciparum malaria. To produce specific antibodies to artesunate, the carboxyl group of artesunate was directly conjugated to carrier protein as the immunogen. A specific monoclonal antibody (mAb) 3D82G6 against artesunate was obtained by high-throughput screening of positive hybridoma clones. This monoclonal antibody had 4.0, 0.5, and 0.9 % cross reactivities with artemisinin, dihydroartemisinin, and artemether, respectively. A dipstick immunoassay was developed, and the indicator range for artesunate was 1000-2000 ng mL(-1). No interference was observed with artemisinin, dihydroartemisinin, artemether, and other commonly used antimalarial drugs for up to 20,000 ng mL(-1). The dipsticks were used for determination of artesunate contents in commercial drugs, and the results were agreeable with those determined by high-performance liquid chromatography. This dipstick, with its specificity and sensitivity for artesunate and simplicity to use, makes it a potential point-of-care device for rapid quality evaluation of artesunate-containing antimalarial drugs. Graphical Abstract Specific monoclonal antibody-based lateral flow dipstick for artesunate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.