ArticleIndian journal of gastroenterology : official journal of the Indian Society of Gastroenterology2016
Non-HFE iron overload as a surrogate marker of disease severity in patients of liver cirrhosis.
Article in Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 3 citations in OpenAlex.
- Immune Dysfunction in Cirrhosis.Journal of clinical and translational hepatology · 2017Review
- Hemochromatosis in India: First Report of Whole Exome Sequencing With Review of the Literature.Journal of clinical and experimental hepatologyArticle
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3 authors at 1 institution in 1 country.
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Abstract
backgroundDecompensated liver cirrhosis is an important cause of mortality worldwide. Various modifiable and non-modifiable factors are involved in the pathogenesis of cirrhosis and its complications. This study was aimed to evaluate the association of iron overload and disease severity in patients of liver cirrhosis and its association with HFE gene mutation.
methodsForty-nine patients with decompensated liver cirrhosis were recruited. Clinical and laboratory parameters were compared in patients with and without iron overload. C282Y and H63D gene mutation analysis was performed in all patients with iron overload.
resultsIron overload was found in 20 (40.82%) patients. A significant positive correlation of transferrin saturation with Child-Turcotte-Pugh (CTP) score (r = 0.705, p < 0.001) and model for end-stage liver disease (MELD) score (r = 0.668, p < 0.001) was found. Transferrin saturation was also independently associated with high CTP and MELD score on multivariate analysis. Mortality over 3 months was significantly more common in iron-overloaded patients (p = 0.028). C282Y homozygosity or C282Y/H63D compound heterozygosity was not found in any of the patients with iron overload.
conclusionIron overload was significantly associated with disease severity and reduced survival in patients of decompensated liver cirrhosis.
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