ReviewCurrent topics in behavioral neurosciences
Translational Assessment of Reward and Motivational Deficits in Psychiatric Disorders.
Review in Current topics in behavioral neurosciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05487885 (Anhedonia, Development, and Emotions), which is not on this map. Cited by 81 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Anhedonia, Development, and Emotions: Phenotyping and Therapeutics (ADEPT) Study
Who cites it
81 citing papers in PubMed.
- Oxytocin differentially modulates reward system responses to social and non-social incentives.Psychopharmacology · 2025Trial
- Depression Severity Moderates Reward Learning Among Smokers With Current or Past Major Depressive Disorder in a Smoking Cessation Randomized Clinical Trial.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2024Trial
- No effect of a dopaminergic modulation fMRI task by amisulpride and L-DOPA on reward anticipation in healthy volunteers.Psychopharmacology · 2021Trial
- Inducing illusory control ensures persistence when rewards fade and when others outperform us.Psychonomic bulletin & review · 2020Trial
- Effect of valproate and pregabalin on human anxiety-like behaviour in a randomised controlled trial.Translational psychiatry · 2018Trial
- Individual differences in brain responses to cigarette-related cues and pleasant stimuli in young smokers.Drug and alcohol dependence · 2016Trial
- Effort, timing and choice: a refined rodent effort choice task with excellent sensitivity to dopamine modulators.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Neural response to reward uncertainty in adolescents with mood and anxiety symptoms.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Distinct ensembles in the prelimbic cortex track different measures of motivation for cocaine and water reinforcers.bioRxiv : the preprint server for biology · 2026Article
- Male and female mice are similarly susceptible to chronic nondiscriminatory social defeat stress despite differences in attack frequency from aggressor.Psychopharmacology · 2026Article
- Editorial: Sex as a biological variable in the neurocircuitry of motivated behavior.Frontiers in behavioral neuroscience · 2026Article
- Neonatal striatal volume is associated with infant anhedonia.Journal of affective disorders · 2026Article
- Motivational neurobehavioral abnormalities under a naturalistic goal-conflict task in patients with premenstrual dysphoric disorder.Frontiers in psychiatry · 2026Article
- Leveraging No-Code Digital Platforms for Designing an Integrated Smartphone-Based Ecological Momentary Intervention With Cognitive Behavioral Therapy for Mental Health Care: Development and Usability Study.JMIR formative research · 2025Article
- Cachexia in mice blunts improved cognitive flexibility induced by calorie restriction.Brain, behavior, and immunity · 2025Article
- Within-person associations of daily activity to sleep actigraphy following trauma: Explicating a novel index of risk for major depressive disorder and posttraumatic stress disorder.Journal of psychopathology and clinical science · 2025Article
- Exploring pleasure as a mediator of outcomes in music therapy.BMC complementary medicine and therapies · 2025Article
- Design and validation of novel brain-penetrant HCN channel inhibitors to ameliorate social stress-induced susceptible phenotype.Molecular psychiatry · 2025Article
- Identification of conserved frontal neurophysiological markers of cognitive flexibility in humans and rats.Communications biology · 2025Article
- Cross-species translational paradigms for assessing positive valence system as defined by the RDoC matrix.Journal of neurochemistry · 2025Review
21 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Deficits in reward and motivation are common symptoms characterizing several psychiatric and neurological disorders. Such deficits may include anhedonia, defined as loss of pleasure, as well as impairments in anticipatory pleasure, reward valuation, motivation/effort, and reward learning. This chapter describes recent advances in the development of behavioral tasks used to assess different aspects of reward processing in both humans and non-human animals. While earlier tasks were generally developed independently with limited cross-species correspondence, a newer generation of translational tasks has emerged that are theoretically and procedurally analogous across species and allow parallel testing, data analyses, and interpretation between human and rodent behaviors. Such enhanced conformity between cross-species tasks will facilitate investigation of the neurobiological mechanisms underlying discrete reward and motivated behaviors and is expected to improve our understanding and treatment of neuropsychiatric disorders characterized by reward and motivation deficits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.