Evidence map›Paper›PMID 26872862›Full record

ArticleAntiviral research2016

Meeting report: 4th ISIRV antiviral group conference: Novel antiviral therapies for influenza and other respiratory viruses.

Jennifer L McKimm-Breschkin, Alicia M Fry

Open access · greenAbstract readConference Proceedings
In one paragraph

Article in Antiviral research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 51 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Trial
  4. Review
  5. Article
  6. Influenza Therapeutics in Clinical Practice-Challenges and Recent Advances.Cold Spring Harbor perspectives in medicine · 2021
    Review
  7. Favipiravir in Therapy of Viral Infections.Journal of clinical medicine · 2021
    Review
  8. Article
  9. Observational
  10. Amantadine Treatment for People with COVID-19.Archives of medical research · 2020
    Article
  11. Review
  12. Influenza virus polymerase inhibitors in clinical development.Current opinion in infectious diseases · 2019
    Review
  13. Structural Insights for Anti-Influenza Vaccine Design.Computational and structural biotechnology journal · 2019
    Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Evolution of Influenza A Virus by Mutation and Re-Assortment.International journal of molecular sciences · 2017
    Review
  19. Influenza antivirals currently in late-phase clinical trial.Influenza and other respiratory viruses · 2017
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 3 countries.

Jennifer L McKimm-BreschkinCSIRO, 343 Royal Parade, Parkville, Australia. Electronic address: mck245@csiro.au.
Alicia M FryInfluenza Division, Centers for Disease Control and Prevention, Atlanta, GA, USA. Electronic address: agf1@cdc.gov.
Centers for Disease Control and Prevention · USCommonwealth Scientific and Industrial Research Organisation · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The International Society for Influenza and other Respiratory Virus Diseases (isirv) held its 4th Antiviral Group Conference at the University of Texas on 2-4 June, 2015. With emerging resistance to the drugs currently licensed for treatment and prophylaxis of influenza viruses, primarily the neuraminidase inhibitor oseltamivir phosphate (Tamiflu) and the M2 inhibitors amantadine and rimantadine, and the lack of effective interventions against other respiratory viruses, the 3-day programme focused on the discovery and development of inhibitors of several virus targets and key host cell factors involved in virus replication or mediating the inflammatory response. Virus targets included the influenza haemagglutinin, neuraminidase and M2 proteins, and both the respiratory syncytial virus and influenza polymerases and nucleoproteins. Therapies for rhinoviruses and MERS and SARS coronaviruses were also discussed. With the emerging development of monoclonal antibodies as therapeutics, the potential implications of antibody-dependent enhancement of disease were also addressed. Topics covered all aspects from structural and molecular biology to preclinical and clinical studies. The importance of suitable clinical trial endpoints and regulatory issues were also discussed from the perspectives of both industry and government. This meeting summary provides an overview, not only for the conference participants, but also for those interested in the current status of antivirals for respiratory viruses.

Indexed as

AmantadineAntibody-Dependent EnhancementAntiviral AgentsCoronavirus InfectionsDrug Resistance, ViralEnzyme InhibitorsHumansInfluenza, HumanNeuraminidaseOrthomyxoviridaeOseltamivirPicornaviridae InfectionsRespiratory Tract InfectionsRimantadineSevere Acute Respiratory SyndromeTexasAmantadineAntiviral AgentsEnzyme InhibitorsNeuraminidaseOseltamivirRimantadineAntiviralInfluenzaIsirv-AVGRespiratory virus

Identifiers

PMID26872862
PMCPMC7132401
OpenAlexW2270371264

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.