Evidence map›Paper›PMID 26872841›Full record

ArticleThe Journal of urology2016

The Relationship between Intolerance of Uncertainty and Anxiety in Men on Active Surveillance for Prostate Cancer.

Hung-Jui Tan, Leonard S Marks, Michael A Hoyt, Lorna Kwan, Christopher P Filson, Malu Macairan, Patricia Lieu, Mark S Litwin, Annette L Stanton

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of urology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Effects of exercise during active surveillance for prostate cancer: A systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hung-Jui TanVeterans Affairs/UCLA Robert Wood Johnson Clinical Scholars Program, University of California-Los Angeles, Los Angeles, California; Department of Urology, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California. Electronic address: htan@mednet.ucla.edu.
Leonard S MarksDepartment of Urology, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California.
Michael A HoytDepartment of Psychology, Hunter College, City University of New York, New York, New York.
Lorna KwanDepartment of Urology, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California.
Christopher P FilsonDepartment of Urology, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California.
Malu MacairanDepartment of Urology, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California.
Patricia LieuDepartment of Urology, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California.
Mark S LitwinDepartment of Urology, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California; Department of Health Policy and Management, Fielding School of Public Health, University of California-Los Angeles, Los Angeles, California.
Annette L StantonDepartments of Psychology and Psychiatry/Biobehavioral Sciences, University of California-Los Angeles, Los Angeles, California; Jonsson Comprehensive Cancer Center, University of California-Los Angeles, Los Angeles, California.

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
Biopsy Tracking and MRI Fusion to Enhance Imaging of Cancer Within the ProstateR01CA158627 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MARKS, LEONARD STEPHEN · 2011 to 2013
$1.4M
NCATS NIH HHS UL1 TR000124NCI NIH HHS R01 CA158627
6 · The paper itself

Abstract

purposeAnxiety may serve as a major barrier to participation in active surveillance. Intolerance of uncertainty, that is the tendency to perceive the potential for negative events as threatening, has been linked to cancer related worry. Accordingly we explored prospectively the relationship of intolerance of uncertainty with anxiety along with other clinical factors among men treated with active surveillance for prostate cancer. MATERIALS AND

methodsA total of 119 men with D'Amico low risk prostate cancer participating in active surveillance completed the HADS (Hospital Anxiety and Depression Scale), MAX-PC (Memorial Anxiety Scale for Prostate Cancer), IUS (Intolerance of Uncertainty Scale) and I-PSS (International Prostate Symptom Score) surveys from 2011 to 2014. We evaluated the relationship between anxiety and IUS score after adjusting for patient characteristics, cancer information and I-PSS using bivariable and multivariable analyses.

resultsOf the men 18 (15.1%) and 17 (14.3%) reported clinically significant anxiety on the generalized and prostate cancer specific scales, respectively. On bivariable analysis men with moderate/severe urinary symptoms and higher IUS scores reported more generalized and prostate cancer specific anxiety than men with mild urinary symptoms and lower IUS scores, respectively (p ≤0.008). Men with depressive symptoms (p = 0.024) or a family history of prostate cancer (p = 0.006) experienced greater generalized anxiety. On multivariable analysis IUS score was significantly associated with generalized and prostate cancer specific anxiety (OR 1.22, 95% CI 1.09-1.38 and OR 1.29, 95% CI 1.13-1.49, respectively) while moderate/severe urinary symptoms were associated with prostate cancer specific anxiety (OR 6.89, 95% CI 1.33-35.68).

conclusionsIntolerance of uncertainty and urinary symptoms may promote anxiety in men on active surveillance for prostate cancer. Patient education, management of lower urinary tract symptoms and behavioral interventions may lessen anxiety related to uncertainty intolerance and help maintain patient engagement in active surveillance.

Indexed as

AgedAnxietyCohort StudiesHumansLongitudinal StudiesMaleMiddle AgedProspective StudiesProstatic NeoplasmsPsychometricsRegistriesRisk FactorsSurveys and QuestionnairesUncertaintyanxietyprostatic neoplasmsquestionnairesuncertaintywatchful waiting

Identifiers

PMID26872841
PMCPMC4871722

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.