ArticleBioMedicine2016
The contributions of the tissue inhibitor of metalloproteinase-1 genotypes to triple negative breast cancer risk.
Article in BioMedicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 31 citations in OpenAlex.
- From Susceptibility to Disease Severity: Re-Discovering the Clinical Role ofLife (Basel, Switzerland) · 2026Article
- The Contribution of Tissue Inhibitor of Metalloproteinase-2 Genotypes to Breast Cancer Risk in Taiwan.Life (Basel, Switzerland) · 2023Article
- Methoxyhispolon Methyl Ether, a Hispolon Analog, Thwarts the SRC/STAT3/BCL-2 Axis to Provoke Human Triple-Negative Breast Cancer Cell Apoptosis In Vitro.Biomedicines · 2023Article
- Impacts ofBiomedicines · 2023Article
- Germline Variants in Angiogenesis-Related Genes Contribute to Clinical Outcome in Head and Neck Squamous Cell Carcinoma.Cancers · 2022Article
- Impacts of RETN genetic polymorphism on breast cancer development.Journal of Cancer · 2020Article
- Impact of WNT1-inducible signaling pathway protein-1 (WISP-1) genetic polymorphisms and clinical aspects of breast cancer.Medicine · 2019Observational
- Association between oral corticosteroid use and pyogenic liver abscesses in a case-control study.BioMedicine · 2018Article
- Contribution of excision repair cross-complementing group 1 genotypes to triple negative breast cancer risk.PloS one · 2018Article
- Correlation betweenInternational journal of medical sciences · 2018Article
- Population-based cohort study investigating the correlation of diabetes mellitus with pleural empyema in adults in Taiwan.Medicine · 2017Observational
- YKL-40-Induced Inhibition of miR-590-3p Promotes Interleukin-18 Expression and Angiogenesis of Endothelial Progenitor Cells.International journal of molecular sciences · 2017Article
- Dipeptidyl Peptidase-4 Inhibitors Use and Relative Risk of Ischemic Cerebrovascular Disease in Type 2 Diabetic Patients in a Case-Control Study.Frontiers in pharmacology · 2017Article
- Case-Control Study Examining the Association between Selective Serotonin Reuptake Inhibitors Use and Hepatocellular Carcinoma.Frontiers in pharmacology · 2017Article
- Increased Risk of Pulmonary Tuberculosis in Patients with Depression: A Cohort Study in Taiwan.Frontiers in psychiatry · 2017Article
- Impacts of CCL4 gene polymorphisms on hepatocellular carcinoma susceptibility and development.International journal of medical sciences · 2017Article
- Zolpidem Administration and Risk of Hepatocellular Carcinoma: A Case-Control Study in Taiwan.Frontiers in pharmacology · 2017Article
- Higher levels of TIMP-1 expression are associated with a poor prognosis in triple-negative breast cancer.Molecular cancer · 2016Article
- The Contribution of PDCD6 Polymorphisms to Oral Cancer Risk.Cancer genomics & proteomicsArticle
- Impacts of Matrix Metalloproteinase-2 Promoter Genotypes on Breast Cancer Risk.Cancer genomics & proteomicsArticle
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The tissue inhibitors of metalloproteinases (TIMPs) are a family of multifunctional proteins which have been shown to be upregulated in various types of cancers. However, the contribution of TIMPs in breast cancer is not fully understood, not to mention triple negative breast cancer (TNBC). This study's aim was to evaluate the contribution of TIMP-1 rs4898, rs6609533, and rs2070584 genotypes to the risk of breast cancer, especially the subtype of TNBC. The contributions of these TIMP-1 genotypes to cancer risk were examined among 1232 breast cancer patients and 1232 healthy controls, and several clinicopathologic factors were also analyzed. The results showed that the percentages of CC, CT, and TT of TIMP-1 rs4898 were differentially distributed at 28.5%, 33.1% and 38.4% in the breast cancer patient group and 34.5%, 41.0% and 24.5% in the control group, respectively (P for trend = 7.99*10(-13)). It was also found that the CC genotype carriers were of increased risk for breast cancer (odds ratio = 1.90, 95% confidence interval = 1.55-2.33, P = 0.0001) than the TT genotype carriers. In addition, we analyzed the allelic frequency distributions of all three TIMP-1s, and the results showed that the C allele of TIMP-1 rs4898 contributes to an increase in breast cancer susceptibility (P = 2.41*10(-12)). On the other hand, there was no difference found in the distribution of genotypic or allelic frequencies among the patients and the controls for TIMP-1 rs6609533 and rs2070584. Thus, it is our conclusion that the CC genotype of TIMP-1 rs4898 compared to the TT wild-type genotype may increase the risk for breast cancer, especially TNBC in Taiwan, and may serve as an early detective and predictive marker.
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