ArticleThe Annals of thoracic surgery2016
Respiratory Effects on Fontan Circulation During Rest and Exercise Using Real-Time Cardiac Magnetic Resonance Imaging.
Article in The Annals of thoracic surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Non-Newtonian Effects on Patient-Specific Modeling of Fontan Hemodynamics.Annals of biomedical engineering · 2020Trial
- Impact of Respiratory Mechanics on Venous Return in Single Ventricle Physiology: A Clinical Imaging Study.JACC. Basic to translational science · 2026Article
- Altered caval flow and wall shear stress in single ventricle circulation: insights from ferumoxytol-enhanced 4D flow MRI.European heart journal. Imaging methods and practice · 2026Article
- Highly accelerated 4D flow MRI with respiratory compensation and cardiac view sharing: a cross-sectional study of flow in the great vessels of pediatric congenital heart disease.Pediatric radiology · 2025Article
- Free-Running Cardiac and Respiratory Motion-Resolved Imaging: A Paradigm Shift for Managing Motion in Cardiac MRI?Diagnostics (Basel, Switzerland) · 2024Review
- Virtual surgery to predict optimized conduit size for adult Fontan patients with 16-mm conduits.Interdisciplinary cardiovascular and thoracic surgery · 2023Article
- Peak Work Rate Increases With Lower Extremity-Focused Exercise Training in Adolescents With Fontan Circulation.Journal of the American Heart Association · 2022Article
- Haemodynamic performance of 16-20-mm extracardiac Goretex conduits in adolescent Fontan patients at rest and during simulated exercise.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2022Article
- Impairments in Pulmonary Function in Fontan Patients: Their Causes and Consequences.Frontiers in pediatrics · 2022Review
- Skeletal muscle deficits are associated with worse exercise performance in pediatric pulmonary hypertension.Frontiers in pediatrics · 2022Article
- Engineering Perspective on Cardiovascular Simulations of Fontan Hemodynamics: Where Do We Stand with a Look Towards Clinical Application.Cardiovascular engineering and technology · 2021Article
- Is Doppler Echocardiography Adequate for Surgical Planning of Single Ventricle Patients?Cardiovascular engineering and technology · 2021Article
- Reduced scan time and superior image quality with 3D flow MRI compared to 4D flow MRI for hemodynamic evaluation of the Fontan pathway.Scientific reports · 2021Article
- Real-time exercise stress cardiac MRI with Fourier-series reconstruction from golden-angle radial data.Magnetic resonance imaging · 2021Article
- The Influence of Respiration on Blood Flow in the Fontan Circulation: Insights for Imaging-Based Clinical Evaluation of the Total Cavopulmonary Connection.Frontiers in cardiovascular medicine · 2021Review
- 5D Flow MRI: A Fully Self-gated, Free-running Framework for Cardiac and Respiratory Motion-resolved 3D Hemodynamics.Radiology. Cardiothoracic imaging · 2020Article
- Exercise cardiovascular magnetic resonance: development, current utility and future applications.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2020Review
- Impact of Free-Breathing Phase-Contrast MRI on Decision-Making in Fontan Surgical Planning.Journal of cardiovascular translational research · 2020Article
- Comparison of Fontan Surgical Options for Patients with Apicocaval Juxtaposition.Pediatric cardiology · 2020Article
- Analysis of Inlet Velocity Profiles in Numerical Assessment of Fontan Hemodynamics.Annals of biomedical engineering · 2019Article
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8 authors.
Funding
Abstract
backgroundIt is known that respiration modulates cavopulmonary flows, but little data compare mean flows under breath-holding and free-breathing conditions to isolate the respiratory effects and effects of exercise on the respiratory modulation.
methodsReal-time phase-contrast magnetic resonance combined with a novel method to track respiration on the same image acquisition was used to investigate respiratory effects on Fontan caval and aortic flows under breath-holding, free-breathing, and exercise conditions. Respiratory phasicity indices that were based on beat-averaged flow were used to quantify the respiratory effect.
resultsFlow during inspiration was substantially higher than expiration under the free-breathing and exercise conditions for both inferior vena cava (inspiration/expiration: 1.6 ± 0.5 and 1.8 ± 0.5, respectively) and superior vena cava (inspiration/expiration: 1.9 ± 0.6 and 2.6 ± 2.0, respectively). Changes from rest to exercise in the respiratory phasicity index for these vessels further showed the impact of respiration. Total systemic venous flow showed no significant statistical difference between the breath-holding and free-breathing conditions. In addition, no substantial difference was found between the descending aorta and inferior vena cava mean flows under either resting or exercise conditions.
conclusionsThis study demonstrated that inferior vena cava and superior vena cava flow time variance is dominated by respiratory effects, which can be detected by the respiratory phasicity index. However, the minimal respiration influence on net flow validates the routine use of breath-holding techniques to measure mean flows in Fontan patients. Moreover, the mean flows in the inferior vena cava and descending aorta are interchangeable.
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