Evidence map›Paper›PMID 26872571›Full record

ReviewNeurourology and urodynamics2016

Do we need to know more about the effects of hormones on lower urinary tract dysfunction? ICI-RS 2014.

Ann T Hanna-Mitchell, Dudley Robinson, Linda Cardozo, Karel Everaert, Georgi V Petkov

Open access · bronzeAbstract readReview
In one paragraph

Review in Neurourology and urodynamics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
3.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 53 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Vitamin D and vitamin BAnnals of medicine · 2024
    Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 3 countries.

Ann T Hanna-MitchellDepartment of Urology, Urology Institute, Case Western Reserve University School of Medicine, Cleveland, Ohio.
Dudley RobinsonDepartment of Urogynecology, King's College Hospital, Denmark Hill, London, United Kingdom.
Linda CardozoDepartment of Urogynecology, King's College Hospital, Denmark Hill, London, United Kingdom.
Karel EveraertDepartment of Urology, Ghent University Hospital, Ghent, Belgium.
Georgi V PetkovDepartment of Drug Discovery and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina, Columbia, South Carolina.
King's College Hospital · GBGhent University Hospital · BEUniversity of South Carolina · USUniversity School · US

Funding

Role of TRP channels in human detrusor function and dysfunctionR01DK106964 · NIDDK · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI XIN, WENKUAN · 2015 to 2019
$1.7M
BK Channel Function and Regulation in Urinary Bladder Smooth MuscleR01DK084284 · NIDDK · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI PETKOV, GEORGI V · 2009 to 2013
$1.6M
NIDDK NIH HHS R01 DK084284NIDDK NIH HHS R01 DK106964
6 · The paper itself

Abstract

This review article reflects the presentations and subsequent discussions during a think tank at the 5th International Consultation on Incontinence Research Society's annual meeting, held in Bristol, UK (September 22-24, 2014). It reviews the current state of knowledge on the role of hormones in lower urinary tract dysfunction (LUTD) and overactive bladder (OAB) and in particular: highlights some specific basic research findings from discussion participants; reviews future research topics; and discusses potential new therapeutic opportunities for LUTD and OAB. The role of the large conductance voltage- and Ca(2+) -activated K(+) (BK) channels, as novel therapeutic targets for OAB was discussed, in particular as recent studies on human detrusor smooth muscle suggest that estradiol exerts a direct non-genomic activation of the BK channels. Recent developments on the roles of sex hormones on diuresis, as well as the roles of melatonin and vitamin D on LUTD were also discussed. It was concluded that further basic science and translational studies are needed to better understand hormonal regulatory mechanisms of the lower urinary tract and the implications for novel treatment options for LUTD and OAB.

Indexed as

HormonesLower Urinary Tract SymptomsUrinary BladderUrinary Bladder, OveractiveAnimalsCongresses as TopicConsensus Statements as TopicEstrogen Replacement TherapyHumansHormonesBK channeldetrusor overactivityestrogenlower urinary tract dysfunctionmelatoninoveractive bladdervasopressinvitamin D3

Identifiers

PMID26872571
PMCPMC6103166
OpenAlexW2262311187

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.