ReviewJournal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology2016
Precision Medicine for Tobacco Dependence: Development and Validation of the Nicotine Metabolite Ratio.
Review in Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed.
- Pharmacokinetics and Pharmacodynamics of Inhaled Nicotine Salt and Free-Base Using an E-cigarette: A Randomized Crossover Study.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2024Trial
- Relationships Between the Nicotine Metabolite Ratio and Laboratory Assessments of Smoking Reinforcement and Craving Among Adults in a Smoking Cessation Trial.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2024Trial
- Correlates of the nicotine metabolite ratio in Alaska Native people who smoke cigarettes.Experimental and clinical psychopharmacology · 2022Trial
- Comparing the Rate of Nicotine Metabolism Among Smokers With Current or Past Major Depressive Disorder.The American journal on addictions · 2021Trial
- Nicotine delivery and relief of craving after consumption of European JUUL e-cigarettes prior and after pod modification.Scientific reports · 2021Trial
- Cigarette Smokers Versus Cousers of Cannabis and Cigarettes: Exposure to Toxicants.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2020Trial
- Trial
- Individual variations in motives for nicotine self-administration in male rats: evidence in support for a precision psychopharmacology.Translational psychiatry · 2024Article
- Small pouches, but high nicotine doses-nicotine delivery and acute effects after use of tobacco-free nicotine pouches.Frontiers in pharmacology · 2024Article
- Article
- Prevalence and trends of cigarette smoking among adults with HIV infection compared with the general population in Korea.Epidemiology and health · 2024Article
- Can Treatment Support Mitigate Nicotine Metabolism-Based Disparities in Smoking Abstinence? Secondary Analysis of the Helping HAND 4 Trial.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2023Article
- Article
- Usage Pattern and Nicotine Delivery during Ad Libitum Consumption of Pod E-Cigarettes and Heated Tobacco Products.Toxics · 2023Article
- Examining racial differences in smoking outcomes among smokers enrolled in an intravenous nicotine infusion study.Addictive behaviors · 2023Article
- The Associations ofInternational journal of environmental research and public health · 2023Article
- Variation in Nicotine Metabolization According to Biological Factors and Type of Nicotine Consumer.Healthcare (Basel, Switzerland) · 2023Article
- Exploring Potential for a Personalized Medicine Approach to Smoking Cessation With an American Indian Tribe.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2023Article
- Changes in synaptic markers after administration of ketamine or psychedelics: a systematic scoping review.Frontiers in psychiatry · 2023Article
- Effects of excessive alcohol drinking on nicotine biotransformation in rats.Scientific reports · 2022Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Quitting smoking significantly reduces the risk of tobacco-related morbidity and mortality, yet there is a high rate of relapse amongst smokers who try to quit. Phenotypic biomarkers have the potential to improve smoking cessation outcomes by identifying the best available treatment for an individual smoker. In this review, we introduce the nicotine metabolite ratio (NMR) as a reliable and stable phenotypic measure of nicotine metabolism that can guide smoking cessation treatment among smokers who wish to quit. We address how the NMR accounts for sources of variation in nicotine metabolism including genotype and other biological and environmental factors such as estrogen levels, alcohol use, body mass index, or menthol exposure. Then, we highlight clinical trials that validate the NMR as a biomarker to predict therapeutic response to different pharmacotherapies for smoking cessation. Current evidence supports the use of nicotine replacement therapy for slow metabolizers, and non-nicotine treatments such as varenicline for normal metabolizers. Finally, we discuss future research directions to elucidate mechanisms underlying NMR associations with treatment response, and facilitate the implementation of the NMR as biomarker in clinical practice to guide smoking cessation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.