ArticlePloS one2016
Surgical Debridement Is Superior to Sole Antibiotic Therapy in a Novel Murine Posttraumatic Osteomyelitis Model.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Conservative versus early surgical treatment in the management of pyogenic spondylodiscitis: a systematic review and meta-analysis.Scientific reports · 2023Pooled it
- Strategies and applications of antibacterial surface-modified biomaterials.Bioactive materials · 2025Review
- Disc penetration sign: an distinctive MRI feature as a predictor of surgical necessity in pyogenic spondylitis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025Article
- Animal Models of Orthopedic Implant-Associated Infections and Revisions.ACS biomaterials science & engineering · 2025Review
- Midterm survival and risk factor analysis in patients with pyogenic vertebral osteomyelitis: a retrospective study of 155 cases.Frontiers in surgery · 2024Article
- Pharmacological elevation of sphingosine-1-phosphate by S1P lyase inhibition accelerates bone regeneration after post-traumatic osteomyelitis.Journal of cellular and molecular medicine · 2023Article
- Choosing the right animal model for osteomyelitis research: Considerations and challenges.Journal of orthopaedic translation · 2023Review
- Wnt3a and ASCs are capable of restoring mineralization in staph aureus-infected primary murine osteoblasts.Journal of bone and mineral metabolism · 2022Article
- Concepts in wound irrigation of open fractures: 'Where we came from, and where are we now?Journal of clinical orthopaedics and trauma · 2021Review
- Wound Irrigation in Orthopedic Open Fractures: A Review.Surgical infections · 2021Review
- Innovations in osteomyelitis research: A review of animal models.Animal models and experimental medicine · 2021Review
- Therapeutics and delivery vehicles for local treatment of osteomyelitis.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020Review
- Local Wnt3a treatment restores bone regeneration in large osseous defects after surgical debridement of osteomyelitis.Journal of molecular medicine (Berlin, Germany) · 2020Article
- Facial trauma followed by osteomyelitis - Case report.International journal of surgery case reports · 2020Article
- Adipose-Derived Stromal Cells Are Capable of Restoring Bone Regeneration After Post-Traumatic Osteomyelitis and Modulate B-Cell Response.Stem cells translational medicine · 2019Article
- A link between osteomyelitis and IL1RN and IL1B polymorphisms-a study in patients from Northeast Brazil.Acta orthopaedica · 2017Article
- Staphylococcus aureus protein A enhances osteoclastogenesis via TNFR1 and EGFR signaling.Biochimica et biophysica acta · 2016Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionBone infections after trauma, i.e. posttraumatic osteomyelitis, pose one of the biggest problems of orthopedic surgery. Even after sufficient clinical therapy including vast debridement of infected bone and antibiotic treatment, regeneration of postinfectious bone seems to be restricted. One explanation includes the large sized defects resulting from sufficient debridement. Furthermore, it remains unclear if inflammatory processes after bone infection do affect bone regeneration. For continuing studies in this field, an animal model is needed where bone regeneration after sufficient treatment can be studied in detail.
methodsFor this purpose we created a stable infection in murine tibiae by Staphylococcus aureus inoculation. Thereafter, osteomyelitic bones were debrided thoroughly and animals were subsequently treated with antibiotics. Controls included debrided, non-infected, as well as infected animals exclusively treated with antibiotics. To verify sufficient treatment of infected bone, different assessments detecting S. aureus were utilized: agar plates, histology and RT-qPCR.
resultsAll three detection methods revealed massive reduction or eradication of S. aureus within debrided bones 1 and 2 weeks postoperatively, whereas sole antibiotic therapy could not provide sufficient treatment of osteomyelitic bones. Debrided, previously infected bones showed significantly decreased bone formation, compared to debrided, non-infected controls. DISCUSSION: Thus, the animal model presented herein provides a reliable and fascinating tool to study posttraumatic osteomyelitis for clinical therapies.
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