ArticleEndocrinology2016
Endothelial Estrogen Receptor-α Does Not Protect Against Vascular Stiffness Induced by Western Diet in Female Mice.
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Article in Endocrinology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
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Who cites it
24 citing papers in PubMed, 26 citations in OpenAlex.
- From protection to predisposition: A narrative review of sex-specific vascular responses to acute stressors across the lifespan.Physiological reports · 2026Review
- Lack of endothelial estrogen receptor alpha signaling exacerbates abdominal aortic aneurysm in male mice.American journal of physiology. Heart and circulatory physiology · 2026Article
- Mineralocorticoid and estrogen receptors as sex-dependent modulators of vascular health in aging and obesity.The Journal of pharmacology and experimental therapeutics · 2025Review
- Lifelong high-fat, high-sucrose diet causes sex-specific heart dysfunction in mouse offspring.Academia medicine · 2025Article
- Understanding the Role of Sex Hormones in Cardiovascular Kidney Metabolic Syndrome: Toward Personalized Therapeutic Approaches.Journal of clinical medicine · 2024Review
- Development of a comprehensive risk prediction model for arterial stiffness assessment in individuals with obesity.Frontiers in medicine · 2024Article
- Endothelial ERα promotes glucose tolerance by enhancing endothelial insulin transport to skeletal muscle.Nature communications · 2023Article
- Estrogen-mediated mechanisms in hypertension and other cardiovascular diseases.Journal of human hypertension · 2023Review
- The Influence of Dietary Interventions on Arterial Stiffness in Overweight and Obese Subjects.Nutrients · 2023Review
- Cystamine reduces vascular stiffness in Western diet-fed female mice.American journal of physiology. Heart and circulatory physiology · 2022Article
- Western diet augments metabolic and arterial dysfunction in a sex-specific manner in outbred, genetically diverse mice.Frontiers in nutrition · 2022Article
- Mineralocorticoid Receptor in Myeloid Cells Mediates Angiotensin II-Induced Vascular Dysfunction in Female Mice.Frontiers in physiology · 2021Article
- Obesity and cardiovascular disease in women.International journal of obesity (2005) · 2020Review
- The Impact of Estrogen Receptor in Arterial and Lymphatic Vascular Diseases.International journal of molecular sciences · 2020Review
- Sexual Dimorphism in Obesity-Associated Endothelial ENaC Activity and Stiffening in Mice.Endocrinology · 2019Article
- Sex differences in mechanisms of arterial stiffness.British journal of pharmacology · 2019Review
- Endothelial Mineralocorticoid Receptors Contribute to Vascular Inflammation in Atherosclerosis in a Sex-Specific Manner.Arteriosclerosis, thrombosis, and vascular biology · 2019Article
- Evidence of sex differences in the acute impact of oscillatory shear stress on endothelial function.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- New insights into arterial stiffening: does sex matter?American journal of physiology. Heart and circulatory physiology · 2018Review
- Cellular mechanisms underlying obesity-induced arterial stiffness.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Review
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Camila ManriqueDivision of Endocrinology, Diabetes and Metabolism (V.G.D., G.L., G.J., A.R.A., C.M., J.R.S., D.H., D.C., B.J.B., M.G.), Department of Medicine, University of Missouri Columbia School of Medicine, Columbia, Missouri 65212; Department of Medical Pharmacology and Physiology (65212) (V.G.D., F.I.R.-P., L.A.M.-L., J.R.S.) and Research Service (V.G.D., J.R.S.), Harry S Truman Memorial Veterans Hospital, Columbia, Missouri 65201; Dalton Cardiovascular Research Center (F.I.R.-P., L.A.M.-L., J.P.), University of Missouri, Columbia, Missouri 65201; Department of Nutrition and Exercise Physiology (J.P.), University of Missouri, Columbia, Missouri 65211; and Departments of Child Health (65201) (J.P.) and Biological Engineering (L.A.M.-L., F.I.R.-P.), University of Missouri, Columbia, Missouri 65211.
Guido LastraDivision of Endocrinology, Diabetes and Metabolism (V.G.D., G.L., G.J., A.R.A., C.M., J.R.S., D.H., D.C., B.J.B., M.G.), Department of Medicine, University of Missouri Columbia School of Medicine, Columbia, Missouri 65212; Department of Medical Pharmacology and Physiology (65212) (V.G.D., F.I.R.-P., L.A.M.-L., J.R.S.) and Research Service (V.G.D., J.R.S.), Harry S Truman Memorial Veterans Hospital, Columbia, Missouri 65201; Dalton Cardiovascular Research Center (F.I.R.-P., L.A.M.-L., J.P.), University of Missouri, Columbia, Missouri 65201; Department of Nutrition and Exercise Physiology (J.P.), University of Missouri, Columbia, Missouri 65211; and Departments of Child Health (65201) (J.P.) and Biological Engineering (L.A.M.-L., F.I.R.-P.), University of Missouri, Columbia, Missouri 65211.
Francisco I Ramirez-PerezDivision of Endocrinology, Diabetes and Metabolism (V.G.D., G.L., G.J., A.R.A., C.M., J.R.S., D.H., D.C., B.J.B., M.G.), Department of Medicine, University of Missouri Columbia School of Medicine, Columbia, Missouri 65212; Department of Medical Pharmacology and Physiology (65212) (V.G.D., F.I.R.-P., L.A.M.-L., J.R.S.) and Research Service (V.G.D., J.R.S.), Harry S Truman Memorial Veterans Hospital, Columbia, Missouri 65201; Dalton Cardiovascular Research Center (F.I.R.-P., L.A.M.-L., J.P.), University of Missouri, Columbia, Missouri 65201; Department of Nutrition and Exercise Physiology (J.P.), University of Missouri, Columbia, Missouri 65211; and Departments of Child Health (65201) (J.P.) and Biological Engineering (L.A.M.-L., F.I.R.-P.), University of Missouri, Columbia, Missouri 65211.
Dominic HaertlingDivision of Endocrinology, Diabetes and Metabolism (V.G.D., G.L., G.J., A.R.A., C.M., J.R.S., D.H., D.C., B.J.B., M.G.), Department of Medicine, University of Missouri Columbia School of Medicine, Columbia, Missouri 65212; Department of Medical Pharmacology and Physiology (65212) (V.G.D., F.I.R.-P., L.A.M.-L., J.R.S.) and Research Service (V.G.D., J.R.S.), Harry S Truman Memorial Veterans Hospital, Columbia, Missouri 65201; Dalton Cardiovascular Research Center (F.I.R.-P., L.A.M.-L., J.P.), University of Missouri, Columbia, Missouri 65201; Department of Nutrition and Exercise Physiology (J.P.), University of Missouri, Columbia, Missouri 65211; and Departments of Child Health (65201) (J.P.) and Biological Engineering (L.A.M.-L., F.I.R.-P.), University of Missouri, Columbia, Missouri 65211.
Vincent G DeMarcoDivision of Endocrinology, Diabetes and Metabolism (V.G.D., G.L., G.J., A.R.A., C.M., J.R.S., D.H., D.C., B.J.B., M.G.), Department of Medicine, University of Missouri Columbia School of Medicine, Columbia, Missouri 65212; Department of Medical Pharmacology and Physiology (65212) (V.G.D., F.I.R.-P., L.A.M.-L., J.R.S.) and Research Service (V.G.D., J.R.S.), Harry S Truman Memorial Veterans Hospital, Columbia, Missouri 65201; Dalton Cardiovascular Research Center (F.I.R.-P., L.A.M.-L., J.P.), University of Missouri, Columbia, Missouri 65201; Department of Nutrition and Exercise Physiology (J.P.), University of Missouri, Columbia, Missouri 65211; and Departments of Child Health (65201) (J.P.) and Biological Engineering (L.A.M.-L., F.I.R.-P.), University of Missouri, Columbia, Missouri 65211.
Annayya R AroorDivision of Endocrinology, Diabetes and Metabolism (V.G.D., G.L., G.J., A.R.A., C.M., J.R.S., D.H., D.C., B.J.B., M.G.), Department of Medicine, University of Missouri Columbia School of Medicine, Columbia, Missouri 65212; Department of Medical Pharmacology and Physiology (65212) (V.G.D., F.I.R.-P., L.A.M.-L., J.R.S.) and Research Service (V.G.D., J.R.S.), Harry S Truman Memorial Veterans Hospital, Columbia, Missouri 65201; Dalton Cardiovascular Research Center (F.I.R.-P., L.A.M.-L., J.P.), University of Missouri, Columbia, Missouri 65201; Department of Nutrition and Exercise Physiology (J.P.), University of Missouri, Columbia, Missouri 65211; and Departments of Child Health (65201) (J.P.) and Biological Engineering (L.A.M.-L., F.I.R.-P.), University of Missouri, Columbia, Missouri 65211.
Guanghong JiaDivision of Endocrinology, Diabetes and Metabolism (V.G.D., G.L., G.J., A.R.A., C.M., J.R.S., D.H., D.C., B.J.B., M.G.), Department of Medicine, University of Missouri Columbia School of Medicine, Columbia, Missouri 65212; Department of Medical Pharmacology and Physiology (65212) (V.G.D., F.I.R.-P., L.A.M.-L., J.R.S.) and Research Service (V.G.D., J.R.S.), Harry S Truman Memorial Veterans Hospital, Columbia, Missouri 65201; Dalton Cardiovascular Research Center (F.I.R.-P., L.A.M.-L., J.P.), University of Missouri, Columbia, Missouri 65201; Department of Nutrition and Exercise Physiology (J.P.), University of Missouri, Columbia, Missouri 65211; and Departments of Child Health (65201) (J.P.) and Biological Engineering (L.A.M.-L., F.I.R.-P.), University of Missouri, Columbia, Missouri 65211.
Dongqing ChenDivision of Endocrinology, Diabetes and Metabolism (V.G.D., G.L., G.J., A.R.A., C.M., J.R.S., D.H., D.C., B.J.B., M.G.), Department of Medicine, University of Missouri Columbia School of Medicine, Columbia, Missouri 65212; Department of Medical Pharmacology and Physiology (65212) (V.G.D., F.I.R.-P., L.A.M.-L., J.R.S.) and Research Service (V.G.D., J.R.S.), Harry S Truman Memorial Veterans Hospital, Columbia, Missouri 65201; Dalton Cardiovascular Research Center (F.I.R.-P., L.A.M.-L., J.P.), University of Missouri, Columbia, Missouri 65201; Department of Nutrition and Exercise Physiology (J.P.), University of Missouri, Columbia, Missouri 65211; and Departments of Child Health (65201) (J.P.) and Biological Engineering (L.A.M.-L., F.I.R.-P.), University of Missouri, Columbia, Missouri 65211.
Brady J BarronDivision of Endocrinology, Diabetes and Metabolism (V.G.D., G.L., G.J., A.R.A., C.M., J.R.S., D.H., D.C., B.J.B., M.G.), Department of Medicine, University of Missouri Columbia School of Medicine, Columbia, Missouri 65212; Department of Medical Pharmacology and Physiology (65212) (V.G.D., F.I.R.-P., L.A.M.-L., J.R.S.) and Research Service (V.G.D., J.R.S.), Harry S Truman Memorial Veterans Hospital, Columbia, Missouri 65201; Dalton Cardiovascular Research Center (F.I.R.-P., L.A.M.-L., J.P.), University of Missouri, Columbia, Missouri 65201; Department of Nutrition and Exercise Physiology (J.P.), University of Missouri, Columbia, Missouri 65211; and Departments of Child Health (65201) (J.P.) and Biological Engineering (L.A.M.-L., F.I.R.-P.), University of Missouri, Columbia, Missouri 65211.
Mona GarroDivision of Endocrinology, Diabetes and Metabolism (V.G.D., G.L., G.J., A.R.A., C.M., J.R.S., D.H., D.C., B.J.B., M.G.), Department of Medicine, University of Missouri Columbia School of Medicine, Columbia, Missouri 65212; Department of Medical Pharmacology and Physiology (65212) (V.G.D., F.I.R.-P., L.A.M.-L., J.R.S.) and Research Service (V.G.D., J.R.S.), Harry S Truman Memorial Veterans Hospital, Columbia, Missouri 65201; Dalton Cardiovascular Research Center (F.I.R.-P., L.A.M.-L., J.P.), University of Missouri, Columbia, Missouri 65201; Department of Nutrition and Exercise Physiology (J.P.), University of Missouri, Columbia, Missouri 65211; and Departments of Child Health (65201) (J.P.) and Biological Engineering (L.A.M.-L., F.I.R.-P.), University of Missouri, Columbia, Missouri 65211.
Jaume PadillaDivision of Endocrinology, Diabetes and Metabolism (V.G.D., G.L., G.J., A.R.A., C.M., J.R.S., D.H., D.C., B.J.B., M.G.), Department of Medicine, University of Missouri Columbia School of Medicine, Columbia, Missouri 65212; Department of Medical Pharmacology and Physiology (65212) (V.G.D., F.I.R.-P., L.A.M.-L., J.R.S.) and Research Service (V.G.D., J.R.S.), Harry S Truman Memorial Veterans Hospital, Columbia, Missouri 65201; Dalton Cardiovascular Research Center (F.I.R.-P., L.A.M.-L., J.P.), University of Missouri, Columbia, Missouri 65201; Department of Nutrition and Exercise Physiology (J.P.), University of Missouri, Columbia, Missouri 65211; and Departments of Child Health (65201) (J.P.) and Biological Engineering (L.A.M.-L., F.I.R.-P.), University of Missouri, Columbia, Missouri 65211.
Luis A Martinez-LemusDivision of Endocrinology, Diabetes and Metabolism (V.G.D., G.L., G.J., A.R.A., C.M., J.R.S., D.H., D.C., B.J.B., M.G.), Department of Medicine, University of Missouri Columbia School of Medicine, Columbia, Missouri 65212; Department of Medical Pharmacology and Physiology (65212) (V.G.D., F.I.R.-P., L.A.M.-L., J.R.S.) and Research Service (V.G.D., J.R.S.), Harry S Truman Memorial Veterans Hospital, Columbia, Missouri 65201; Dalton Cardiovascular Research Center (F.I.R.-P., L.A.M.-L., J.P.), University of Missouri, Columbia, Missouri 65201; Department of Nutrition and Exercise Physiology (J.P.), University of Missouri, Columbia, Missouri 65211; and Departments of Child Health (65201) (J.P.) and Biological Engineering (L.A.M.-L., F.I.R.-P.), University of Missouri, Columbia, Missouri 65211.
James R SowersDivision of Endocrinology, Diabetes and Metabolism (V.G.D., G.L., G.J., A.R.A., C.M., J.R.S., D.H., D.C., B.J.B., M.G.), Department of Medicine, University of Missouri Columbia School of Medicine, Columbia, Missouri 65212; Department of Medical Pharmacology and Physiology (65212) (V.G.D., F.I.R.-P., L.A.M.-L., J.R.S.) and Research Service (V.G.D., J.R.S.), Harry S Truman Memorial Veterans Hospital, Columbia, Missouri 65201; Dalton Cardiovascular Research Center (F.I.R.-P., L.A.M.-L., J.P.), University of Missouri, Columbia, Missouri 65201; Department of Nutrition and Exercise Physiology (J.P.), University of Missouri, Columbia, Missouri 65211; and Departments of Child Health (65201) (J.P.) and Biological Engineering (L.A.M.-L., F.I.R.-P.), University of Missouri, Columbia, Missouri 65211.
University of Missouri · USUniversity of Missouri Health System · US
Funding
ANG II OPPOSES INS MEDIATED VASORELAXATION &GLU UTILZAR01HL073101 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI SOWERS, JAMES RUSSELL · 2004 to 2013
$2.7MAng II and Overnutrition and Insulin resistance in Cardiovascular TissueR01HL107910 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI SOWERS, JAMES RUSSELL · 2011 to 2015
$1.8MMineralocorticoid and estrogen receptor alpha signaling in the pathogenesis of vascular stiffness in insulin resistant femalesK08HL129074 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI MANRIQUE ACEVEDO, CAMILA MARGARITA · 2015 to 2019
$802kVascular Insulin Resistance in Obesity: Role of Endoplasmic Reticulum StressK01HL125503 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI PADILLA, JAUME · 2015 to 2018
$564kInteractions of the RAAS and a Western Diet on Insulin Metabolic ActionsI01BX001981 · VA · HARRY S. TRUMAN MEMORIAL VA HOSPITAL · PI LASTRA, GUIDO · 2013 to 2022
–BLRD VA I01 BX001981NHLBI NIH HHS 1K08HL129074-01NHLBI NIH HHS K01 HL125503NHLBI NIH HHS K01HL125503NHLBI NIH HHS K08 HL129074NHLBI NIH HHS R01 HL073101NHLBI NIH HHS R01-HL073101NHLBI NIH HHS R01 HL107910NHLBI NIH HHS R01-HL107910
Abstract
Consumption of a diet high in fat and refined carbohydrates (Western diet [WD]) is associated with obesity and insulin resistance, both major risk factors for cardiovascular disease (CVD). In women, obesity and insulin resistance abrogate the protection against CVD likely afforded by estrogen signaling through estrogen receptor (ER)α. Indeed, WD in females results in increased vascular stiffness, which is independently associated with CVD. We tested the hypothesis that loss of ERα signaling in the endothelium exacerbates WD-induced vascular stiffening in female mice. We used a novel model of endothelial cell (EC)-specific ERα knockout (EC-ERαKO), obtained after sequential crossing of the ERα double floxed mice and VE-Cadherin Cre-recombinase mice. Ten-week-old females, EC-ERαKO and aged-matched genopairs were fed either a regular chow diet (control diet) or WD for 8 weeks. Vascular stiffness was measured in vivo by pulse wave velocity and ex vivo in aortic explants by atomic force microscopy. In addition, vascular reactivity was assessed in isolated aortic rings. Initial characterization of the model fed a control diet did not reveal changes in whole-body insulin sensitivity, aortic vasoreactivity, or vascular stiffness in the EC-ERαKO mice. Interestingly, ablation of ERα in ECs reduced WD-induced vascular stiffness and improved endothelial-dependent dilation. In the setting of a WD, endothelial ERα signaling contributes to vascular stiffening in females. The precise mechanisms underlying the detrimental effects of endothelial ERα in the setting of a WD remain to be elucidated.
Indexed as
Diet, WesternAnimalsAntigens, CDAorta, ThoracicCadherin 5CadherinsEndothelial CellsEstrogen Receptor alphaFemaleFemoral ArteryImmunoblottingMice, KnockoutMice, TransgenicMicroscopy, Atomic ForcePulse Wave AnalysisTransforming Growth Factor betaAntigens, CDCadherin 5CadherinsEstrogen Receptor alphaTransforming Growth Factor beta
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