Evidence map›Paper›PMID 26871949›Full record

Trial reportNeurogastroenterology and motility2016

Colonic response to laxative ingestion as assessed by MRI differs in constipated irritable bowel syndrome compared to functional constipation.

C Lam, G Chaddock, L Marciani, C Costigan, J Paul, E Cox, C Hoad, A Menys, S Pritchard, K Garsed and 4 more

Open access · hybridAbstract readClinical TrialComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Neurogastroenterology and motility, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 57 citations in OpenAlex.

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  6. Elobixibat Improves Stool/Gas Distribution and Fecal Bile Acids in Older Adults With Chronic Constipation.JGH open : an open access journal of gastroenterology and hepatology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

C LamNIHR Nottingham Digestive Diseases Biomedical Research Unit and Nottingham Digestive Diseases Centre, School of Medicine, University of Nottingham, Nottingham, UK.
G ChaddockSir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, UK.
L MarcianiNIHR Nottingham Digestive Diseases Biomedical Research Unit and Nottingham Digestive Diseases Centre, School of Medicine, University of Nottingham, Nottingham, UK.
C CostiganNIHR Nottingham Digestive Diseases Biomedical Research Unit and Nottingham Digestive Diseases Centre, School of Medicine, University of Nottingham, Nottingham, UK.
J PaulSir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, UK.
E CoxSir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, UK.
C HoadNIHR Nottingham Digestive Diseases Biomedical Research Unit and Nottingham Digestive Diseases Centre, School of Medicine, University of Nottingham, Nottingham, UK.
A MenysCentre for Medical Imaging, Division of Medicine, University College London, London, UK.
S PritchardSir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, UK.
K GarsedRoyal Derby Hospitals Foundation Trust, Derby, UK.
S TaylorCentre for Medical Imaging, Division of Medicine, University College London, London, UK.
D AtkinsonCentre for Medical Imaging, Division of Medicine, University College London, London, UK.
P GowlandSir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, UK.
R SpillerNIHR Nottingham Digestive Diseases Biomedical Research Unit and Nottingham Digestive Diseases Centre, School of Medicine, University of Nottingham, Nottingham, UK.
University of Nottingham · GBUniversity College London · GBNIHR Nottingham Digestive Diseases Biomedical Research Unit · GBRoyal Derby Hospital · GB

Funding

Medical Research Council G1001119Medical Research Council MC_PC_13072
6 · The paper itself

Abstract

backgroundFunctional constipation (FC) and irritable bowel syndrome with constipation (IBS-C) share many symptoms but underlying mechanisms may be different. We have developed a magnetic resonance imaging (MRI) technique to measure intestinal volumes, transit, and motility in response to a laxative, Moviprep(®) . We aim to use these biomarkers to study the pathophysiology in IBS-C and FC.

methodsTwenty-four FC and 24 IBS-C were studied. Transit was assessed using the weighted average position score (WAPS) of five MRI marker pills, taken 24 h before MRI scanning. Following baseline scan, participants ingested 1 L of Moviprep(®) followed by hourly scans. Magnetic resonance imaging parameters and bowel symptoms were scored from 0 to 4 h. KEY

resultsWeighted average position score for FC was 3.6 (2.5-4.2), significantly greater than IBS-C at 2.0 (1.5-3.2), p = 0.01, indicating slower transit for FC. Functional constipation showed greater fasting small bowel water content, 83 (63-142) mL vs 39 (15-70) mL in IBS-C, p < 0.01 and greater ascending colon volume (AC), 314 (101) mL vs 226 (71) mL in IBS-C, p < 0.01. FC motility index was lower at 0.055 (0.044) compared to IBS-C, 0.107 (0.070), p < 0.01. Time to first bowel movement following ingestion of Moviprep(®) was greater for FC, being 295 (116-526) min, compared to IBS-C at 84 (49-111) min, p < 0.01, and correlated with AC volume 2 h after Moviprep(®) , r = 0.44, p < 0.01. Using a cut-off >230 min distinguishes FC from IBS-C with low sensitivity of 55% but high specificity of 95%. CONCLUSION & INFERENCES: Our objective MRI biomarkers allow a distinction between FC and IBS-C.

Indexed as

Magnetic Resonance ImagingAdultColonConstipationFemaleGastrointestinal MotilityGastrointestinal TransitHumansIrritable Bowel SyndromeLaxativesMaleMiddle AgedPolyethylene GlycolsLaxativesMoviPrepPolyethylene Glycolscolonfunctional constipationirritable bowel syndrome with constipationlaxativemotility

Identifiers

PMID26871949
PMCPMC4949702
OpenAlexW2265156854

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.