ArticlePLoS pathogens2016
Species-Specific Adaptations of Trypanosome Morphology and Motility to the Mammalian Host.
Article in PLoS pathogens, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 1 of them a synthesis that pooled it.
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Who cites it
58 citing papers in PubMed, 1 synthesis or guideline pooled it, 111 citations in OpenAlex.
- Trypanosomosis prevalence in natural field-based infection: insights into systematic review and meta-analysis of studies from 1980 to 2018 on The Gambian ruminants with special emphasis on cattle.Tropical animal health and production · 2020Pooled it
- An agent-based model of Trypanosoma brucei social motility to explore determinants of colony pattern formation.PLoS computational biology · 2026Article
- Temperature dependence of the motility of the parasitic microswimmer Trypanosoma brucei.Biophysical journal · 2026Article
- An In Vitro 3D Collagen-I Model for Studying Trypanosoma cruzi Trypomastigote Motility.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Developing a national atlas to support the progressive control of tsetse-transmitted animal trypanosomosis in Zambia.Parasites & vectors · 2025Article
- Modelling motility of Trypanosoma brucei.PLoS computational biology · 2025Article
- Functional morphology of gliding motility in benthic diatoms.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Trypanosome doublet microtubule structures reveal flagellum assembly and motility mechanisms.Science (New York, N.Y.) · 2025Article
- Cell motility influences microfluidics capturing in scRNA-seq.Open research Europe · 2025Article
- Mechanisms of life cycle simplification in African trypanosomes.Nature communications · 2024Article
- FAP20 is required for flagellum assembly inMolecular biology of the cell · 2024Article
- Microbes in porous environments: from active interactions to emergent feedback.Biophysical reviews · 2024Review
- FAP20 is required for flagellum assembly inbioRxiv : the preprint server for biology · 2024Article
- Trajectory-driven computational analysis for element characterization in Trypanosoma cruzi video microscopy.PloS one · 2024Article
- Investigation ofCell surface (Amsterdam, Netherlands) · 2023Article
- Pathogenicity and virulence of African trypanosomes: From laboratory models to clinically relevant hosts.Virulence · 2023Review
- FLAgellum Member 8 modulates extravascular distribution of African trypanosomes.PLoS pathogens · 2023Article
- How colonization bottlenecks, tissue niches, and transmission strategies shape protozoan infections.Trends in parasitology · 2023Review
- The lymphatic system favours survival of a unique T. brucei population.Biology open · 2023Article
- FAP106 is an interaction hub for assembling microtubule inner proteins at the cilium inner junction.Nature communications · 2023Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
African trypanosomes thrive in the bloodstream and tissue spaces of a wide range of mammalian hosts. Infections of cattle cause an enormous socio-economic burden in sub-Saharan Africa. A hallmark of the trypanosome lifestyle is the flagellate's incessant motion. This work details the cell motility behavior of the four livestock-parasites Trypanosoma vivax, T. brucei, T. evansi and T. congolense. The trypanosomes feature distinct swimming patterns, speeds and flagellar wave frequencies, although the basic mechanism of flagellar propulsion is conserved, as is shown by extended single flagellar beat analyses. Three-dimensional analyses of the trypanosomes expose a high degree of dynamic pleomorphism, typified by the 'cellular waveform'. This is a product of the flagellar oscillation, the chirality of the flagellum attachment and the stiffness of the trypanosome cell body. The waveforms are characteristic for each trypanosome species and are influenced by changes of the microenvironment, such as differences in viscosity and the presence of confining obstacles. The distinct cellular waveforms may be reflective of the actual anatomical niches the parasites populate within their mammalian host. T. vivax displays waveforms optimally aligned to the topology of the bloodstream, while the two subspecies T. brucei and T. evansi feature distinct cellular waveforms, both additionally adapted to motion in more confined environments such as tissue spaces. T. congolense reveals a small and stiff waveform, which makes these parasites weak swimmers and destined for cell adherence in low flow areas of the circulation. Thus, our experiments show that the differential dissemination and annidation of trypanosomes in their mammalian hosts may depend on the distinct swimming capabilities of the parasites.
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