ArticlePloS one2016
Trajectories of Pain and Function after Primary Hip and Knee Arthroplasty: The ADAPT Cohort Study.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 62 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
GREAT Knee Pain Reduction Trial, Genicular Radiofrequency Ablation Efficacy in Achieving Total Knee Pain Reduction Trial
Enhancing Functional Outcomes in Total Knee Arthroplasty: the Role of Preoperative Genicular Radiofrequency
Who cites it
62 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Measuring patient disability in the peri-operative period using the WHODAS 2.0 questionnaire: a systematic review.Anaesthesia · 2026Pooled it
- What proportion of people have long-term pain after total hip or knee replacement? An update of a systematic review and meta-analysis.BMJ open · 2025Pooled it
- Peripheral nerve stimulation for chronic knee pain following total knee arthroplasty: a systematic review.Pain management · 2023Pooled it
- Should synovectomy be performed in primary total knee arthroplasty for osteoarthritis? A meta-analysis of randomized controlled trials.Journal of orthopaedic surgery and research · 2019Pooled it
- Pooled it
- Post-operative patient-related risk factors for chronic pain after total knee replacement: a systematic review.BMJ open · 2017Pooled it
- Experiences of recovery and a new care pathway for people with pain after total knee replacement: qualitative research embedded in the STAR trial.BMC musculoskeletal disorders · 2022Trial
- A novel behavioural INTErvention to REduce Sitting Time in older adults undergoing orthopaedic surgery (INTEREST): results of a randomised-controlled feasibility study.Aging clinical and experimental research · 2020Trial
- Validated repeatability of patient-reported outcome measures following primary total hip replacement: a mode of delivery comparison study with randomized sequencing.Acta orthopaedica · 2018Trial
- Course of pain after total hip arthroplasty within a standardized pain management concept: a prospective study examining influence, correlation, and outcome of postoperative pain on 103 consecutive patients.Archives of orthopaedic and trauma surgery · 2018Trial
- Chronic Pain and Stiffness After Total Knee Arthroplasty: A Comprehensive, Phenotype-Based Review of Mechanisms, Diagnosis and Management.Journal of clinical medicine · 2026Review
- Genicular Artery Embolization as a Treatment Option for Refractory Knee Pain Post Total Knee Arthroplasty: A Prospective Series.Cardiovascular and interventional radiology · 2026Article
- Step count recovery patterns in the first six weeks after knee replacement in individuals with knee osteoarthritis: a secondary analysis of a prospective observational cohort study using wrist-worn accelerometry.Rheumatology international · 2026Observational
- Multivariate Profiling of Physical Resilience in Older Adults After Total Knee Replacement Surgery: Results From a Prospective Observational Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Observational
- Management of post-arthroplasty pain: a narrative review of emerging interventional treatments.Pain management · 2025Review
- Bilateral heterotopic ossification following Total knee arthroplasty: The role of cultural practices in postoperative complications: A case report.International journal of surgery case reports · 2025Article
- Chronic postsurgical pain and transitional pain services: a narrative review highlighting European perspectives.Regional anesthesia and pain medicine · 2025Review
- Article
- Predicting Recovery Following Total Hip and Knee Arthroplasty Using a Clustering Algorithm.Arthroplasty today · 2024Article
- The Impact of Acute Postoperative Pain in Developing Chronic Pain after Total Knee Arthroplasty.Neurology international · 2024Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
background and purposePain and function improve dramatically in the first three months after hip and knee arthroplasty but the trajectory after three months is less well described. It is also unclear how pre-operative pain and function influence short- and long-term recovery. We explored the trajectory of change in function and pain until and beyond 3-months post-operatively and the influence of pre-operative self-reported symptoms.
methodsThe study was a prospective cohort study of 164 patients undergoing primary hip (n = 80) or knee (n = 84) arthroplasty in the United Kingdom. Self-reported measures of pain and function using the Western Ontario and McMaster Universities Osteoarthritis index were collected pre-operatively and at 3 and 12 months post-operatively. Hip and knee arthroplasties were analysed separately, and patients were split into two groups: those with high or low symptoms pre-operatively. Multilevel regression models were used for each outcome (pain and function), and the trajectories of change were charted (0-3 months and 3-12 months).
resultsHip: Most improvement occurred within the first 3 months following hip surgery and patients with worse pre-operative scores had greater changes. The mean changes observed between 3 and twelve months were statistically insignificant. One year after surgery, patients with worse pre-operative scores had post-operative outcomes similar to those observed among patients with less severe pre-operative symptoms. Knee: Most improvement occurred in the first 3 months following knee surgery with no significant change thereafter. Despite greater mean change during the first three months, patients with worse pre-operative scores had not 'caught-up' with those with less severe pre-operative symptoms 12 months after their surgery.
conclusionMost symptomatic improvement occurred within the first 3 months after surgery with no significant change between 3-12 months. Further investigations are now required to determine if patients with severe symptoms at the time of their knee arthroplasty have a different pre-surgical history than those with less severe symptoms and if they could benefit from earlier surgical intervention and tailored rehabilitation to achieve better post-operative patient-reported outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.