Evidence map›Paper›PMID 26871808›Full record

SynthesisMedicine2016

Association Between Cd Exposure and Risk of Prostate Cancer: A PRISMA-Compliant Systematic Review and Meta-Analysis.

Song Ju-Kun, Dong-Bo Yuan, Hao-Fu Rao, Tian-Fei Chen, Bo-Shi Luan, Xiao-Ming Xu, Fu-Neng Jiang, Wei-De Zhong, Jian-Guo Zhu

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 4 pooled it
3.1field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 4 syntheses or guidelines pooled it, 71 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. The Association Between Cadmium Exposure and Prostate Cancer: An Updated Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2024
    Pooled it
  4. Pooled it
  5. Article
  6. Smoking and the risk of prostate cancer: a review of risk and disease progression.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2025
    Review
  7. Article
  8. Mechanisms of Heavy Metal Cadmium (Cd)-Induced Malignancy.Biological trace element research · 2025
    Review
  9. Article
  10. Review
  11. Review
  12. An overview of the ameliorative efficacy ofFrontiers in public health · 2024
    Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Song Ju-KunFrom the Department of Oral and maxillofacial surgery (SJ-K), Guizhou Provincial People's Hospital, Guiyang, Guizhou; Department of Urology (D-BY, H-FR, T-FC, B-SL, J-GZ), Guizhou Provincial People's Hospital, Guizhou, Guiyang; Department of Urology (X-MX), Ningbo No. 2 Hospital, Ningbo; Department of Urology (F-NJ, W-DZ, J-GZ), Guangdong Key Laboratory of Clinical Molecular Medicine and Diagnostics, Guangzhou First People's Hospital, Guangzhou Medical University, Guiyang, Guangzhou; and Urology Key Laboratory of Guangdong Province (F-NJ, W-DZ, J-GZ), The First Affiliated, Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China.
Dong-Bo Yuan
Hao-Fu Rao
Tian-Fei Chen
Bo-Shi Luan
Xiao-Ming Xu
Fu-Neng Jiang
Wei-De Zhong
Jian-Guo Zhu
Guiyang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several observational studies on the association between Cd exposure and risk of prostate cancer have yielded inconsistent results. To address this issue, we conducted a meta-analysis to evaluate the correlation between Cd exposure and risk of prostate cancer.Relevant studies in PubMed and Embase databases were retrieved until October 2015. We compared the highest and lowest meta-analyses to quantitatively evaluate the relationship between Cd exposure and risk of prostate cancer. Summary estimates were obtained using a random-effects model.In the general population, high Cd exposure was not associated with increased prostate cancer (OR 1.21; 95% CI 0.91-1.64), whereas the combined standardized mortality ratio of the association between Cd exposure and risk of prostate cancer was 1.66 (95% CI 1.10-2.50) in populations exposed to occupational Cd. In addition, high D-Cd intake (OR 1.07; 95% CI 0.96-1.20) and U-Cd concentration (OR 0.86; 95% CI 0.48-1.55) among the general population was not related to the increased risk of prostate cancer. In the dose analysis, the summary relative risk was 1.07 (95% CI 0.73-1.57) for each 0.5 μg/g creatinine increase in U-Cd and 1.02 (95% CI 0.99-1.06) for each 10 μg/day increase of dietary Cd intake. However, compared with nonoccupational exposure, high occupational Cd exposure may be associated with the increased risk of prostate cancer.This meta-analysis suggests high Cd exposure as a risk factor for prostate cancer in occupational rather than nonoccupational populations. However, these results should be carefully interpreted because of the significant heterogeneity among studies. Additional large-scale and high-quality prospective studies are needed to confirm the association between Cd exposure and risk of prostate cancer.

Indexed as

CadmiumEnvironmental ExposureEnvironmental PollutantsHumansMaleModels, StatisticalOccupational ExposureProstatic NeoplasmsRisk FactorsCadmiumEnvironmental Pollutants

Identifiers

PMID26871808
PMCPMC4753904
OpenAlexW2297182688

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.