Evidence map›Paper›PMID 26871633›Full record

ArticleCell2016

Shelterin Protects Chromosome Ends by Compacting Telomeric Chromatin.

Jigar N Bandaria, Peiwu Qin, Veysel Berk, Steven Chu, Ahmet Yildiz

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers.

0numbers the graph read from it
0cells of the map it votes in
101citing papers in PubMed
12.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

101 citing papers in PubMed, 171 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Protection of the Telomeric Junction by the Shelterin Complex.Journal of the American Chemical Society · 2024
    Article
  11. Protection of the Telomeric Junction by the Shelterin Complex.bioRxiv : the preprint server for biology · 2024
    Article
  12. Aging, Cancer, and Inflammation: The Telomerase Connection.International journal of molecular sciences · 2024
    Review
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Review

41 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jigar N BandariaDepartment of Physics, University of California, Berkeley, Berkeley, CA 94720, USA; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Peiwu QinDepartment of Physics, University of California, Berkeley, Berkeley, CA 94720, USA.
Veysel BerkDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Department of Physics, Stanford University, Stanford, CA 94305, USA.
Steven ChuDepartment of Physics, Stanford University, Stanford, CA 94305, USA.
Ahmet YildizDepartment of Physics, University of California, Berkeley, Berkeley, CA 94720, USA; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address: yildiz@berkeley.edu.
University of California, Berkeley · USStanford University · US

Funding

Understanding the Mechanism and Regulation of the Human Cytoplasmic Dynein ComplexR01GM094522 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI YILDIZ, AHMET · 2011 to 2019
$2.8M
Structural and Functional Characterization of Telomere Protection and MaintenanceR01GM118773 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI YILDIZ, AHMET · 2016 to 2019
$1.2M
NIGMS NIH HHS GM094522NIGMS NIH HHS R01 GM094522NIGMS NIH HHS R01 GM118773
6 · The paper itself

Abstract

Telomeres, repetitive DNA sequences at chromosome ends, are shielded against the DNA damage response (DDR) by the shelterin complex. To understand how shelterin protects telomere ends, we investigated the structural organization of telomeric chromatin in human cells using super-resolution microscopy. We found that telomeres form compact globular structures through a complex network of interactions between shelterin subunits and telomeric DNA, but not by DNA methylation, histone deacetylation, or histone trimethylation at telomeres and subtelomeric regions. Mutations that abrogate shelterin assembly or removal of individual subunits from telomeres cause up to a 10-fold increase in telomere volume. Decompacted telomeres accumulate DDR signals and become more accessible to telomere-associated proteins. Recompaction of telomeric chromatin using an orthogonal method displaces DDR signals from telomeres. These results reveal the chromatin remodeling activity of shelterin and demonstrate that shelterin-mediated compaction of telomeric chromatin provides robust protection of chromosome ends against the DDR machinery.

Indexed as

Chromatin Assembly and DisassemblyDNA DamageDNA RepairHeLa CellsHumansProtein MultimerizationShelterin ComplexTATA Box Binding Protein-Like ProteinsTelomereTelomere-Binding ProteinsTelomeric Repeat Binding Protein 2POT1 protein, humanShelterin ComplexTATA Box Binding Protein-Like ProteinsTBPL1 protein, humanTelomere-Binding ProteinsTelomeric Repeat Binding Protein 2TERF2 protein, humanTINF2 protein, human

Identifiers

PMID26871633
PMCPMC4762449
OpenAlexW2258427811

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.