ArticleEBioMedicine2016
Allergy associations with the adult fecal microbiota: Analysis of the American Gut Project.
Article in EBioMedicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
96 citing papers in PubMed, 1 synthesis or guideline pooled it, 196 citations in OpenAlex.
- The microbiome in allergic disease: Current understanding and future opportunities-2017 PRACTALL document of the American Academy of Allergy, Asthma & Immunology and the European Academy of Allergy and Clinical Immunology.The Journal of allergy and clinical immunology · 2017Guideline
- Trial
- Effect of the Multi-Strain Probiotic SYN-53 in the Management of Allergic Rhinoconjunctivitis.Allergy · 2025Trial
- Gut Microbiome Dynamics in Food Allergy Development Across the Lifespan: Microbial Mechanisms, Host Interactions, and Therapeutic Perspectives.Microorganisms · 2026Review
- A study on the correlation between intestinal flora characteristics and serum zinc and iron levels in paediatric patients with mycoplasma pneumoniae pneumonia.BMC pediatrics · 2026Article
- Gut mucosal immune responses - Implications for celiac disease and food allergy.Seminars in immunology · 2025Review
- Probiotics Attenuate Food Allergy via Short-Chain Fatty Acids-Mediated Immune Modulation and Gut Barrier Restoration.Foods (Basel, Switzerland) · 2025Article
- A Unified Pathogenesis of Allergic Diseases; The Protein-Homeostasis-System Hypothesis.International journal of molecular sciences · 2025Review
- Novel Synbiotic Yogurt Formulation Supplemented with Fucoidan fromFoods (Basel, Switzerland) · 2025Article
- ITIH4 alleviates OVA-induced asthma by regulating lung-gut microbiota.Molecular medicine (Cambridge, Mass.) · 2025Article
- Gut microbiota diversity among humans, elephants, livestock and wild herbivores in Chitwan National Park bears implications for conservation medicine.Scientific reports · 2025Article
- Profiling of the gut, skin and nasal microbiotas revealed clinically relevant microbial taxa from children with allergies: a pilot study.Frontiers in allergy · 2025Article
- Gut Dysbiosis and Adult Atopic Dermatitis: A Systematic Review.Journal of clinical medicine · 2024Review
- Human intestinal microbiome: Role in health and disease.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2024Review
- Routinely Used and Emerging Diagnostic and Immunotherapeutic Approaches for Wheat Allergy.Biomedicines · 2024Review
- The Role of Biodiversity in the Development of Asthma and Allergic Sensitization: A State-of-the-Science Review.Environmental health perspectives · 2024Review
- Gonadal sex and chromosome complement influence the gut microbiome in a mouse model of allergic airway inflammation.Physiological genomics · 2024Article
- Investigation of the relationship between atopic dermatitis of dogs and intestinal epithelial damage.Veterinary medicine and science · 2024Article
- Estimating the overall fraction of phenotypic variance attributed to high-dimensional predictors measured with error.Biostatistics (Oxford, England) · 2024Article
- [Specific changes in gut microbiota and short-chain fatty acid levels in infants with cow's milk protein allergy].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024Article
36 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAlteration of the gut microbial population (dysbiosis) may increase the risk for allergies and other conditions. This study sought to clarify the relationship of dysbiosis with allergies in adults.
methodsPublicly available American Gut Project questionnaire and fecal 16S rRNA sequence data were analyzed. Fecal microbiota richness (number of observed species) and composition (UniFrac) were used to compare adults with versus without allergy to foods (peanuts, tree nuts, shellfish, other) and non-foods (drug, bee sting, dander, asthma, seasonal, eczema). Logistic and Poisson regression models adjusted for potential confounders. Odds ratios and 95% confidence intervals (CI) were calculated for lowest vs highest richness tertile. Taxonomy associations considered 122 non-redundant taxa (of 2379 total taxa) with ≥ 0.1% mean abundance.
resultsSelf-reported allergy prevalence among the 1879 participants (mean age, 45.5 years; 46.9% male) was 81.5%, ranging from 2.5% for peanuts to 40.5% for seasonal. Fecal microbiota richness was markedly lower with total allergies (P = 10(-9)) and five particular allergies (P ≤ 10(-4)). Richness odds ratios were 1.7 (CI 1.3-2.2) with seasonal, 1.8 (CI 1.3-2.5) with drug, and 7.8 (CI 2.3-26.5) with peanut allergy. These allergic participants also had markedly altered microbial community composition (unweighted UniFrac, P = 10(-4) to 10(-7)). Total food and non-food allergies were significantly associated with 7 and 9 altered taxa, respectively. The dysbiosis was most marked with nut and seasonal allergies, driven by higher Bacteroidales and reduced Clostridiales taxa.
interpretationAmerican adults with allergies, especially to nuts and seasonal pollen, have low diversity, reduced Clostridiales, and increased Bacteroidales in their gut microbiota. This dysbiosis might be targeted to improve treatment or prevention of allergy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.