Evidence map›Paper›PMID 26870735›Full record

ArticleFrontiers in nutrition2016

Effect of Housing Types on Growth, Feeding, Physical Activity, and Anxiety-Like Behavior in Male Sprague-Dawley Rats.

Jennifer A Teske, Claudio Esteban Perez-Leighton, Emily E Noble, Chuanfeng Wang, Charles J Billington, Catherine M Kotz

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Jennifer A TeskeDepartment of Nutritional Sciences, University of Arizona, Tucson, AZ, USA; Minneapolis VA Health Care System, Minneapolis, MN, USA; Minnesota Obesity Center, University of Minnesota, Saint Paul, MN, USA; Department of Food Science and Nutrition, University of Minnesota, Saint Paul, MN, USA.
Claudio Esteban Perez-LeightonDepartment of Food Science and Nutrition, University of Minnesota, Saint Paul, MN, USA; Center for Integrative Medicine and Innovative Science, Universidad Andres Bello, Santiago, Chile.
Emily E NobleDepartment of Integrative Biology and Physiology, University of California Los Angeles , Los Angeles, CA , USA.
Chuanfeng WangMinneapolis VA Health Care System, Minneapolis, MN, USA; Minnesota Obesity Center, University of Minnesota, Saint Paul, MN, USA; Department of Food Science and Nutrition, University of Minnesota, Saint Paul, MN, USA.
Charles J BillingtonMinneapolis VA Health Care System, Minneapolis, MN, USA; Minnesota Obesity Center, University of Minnesota, Saint Paul, MN, USA; Department of Food Science and Nutrition, University of Minnesota, Saint Paul, MN, USA; Department of Medicine, University of Minnesota, Minneapolis, MN, USA.
Catherine M KotzMinneapolis VA Health Care System, Minneapolis, MN, USA; Minnesota Obesity Center, University of Minnesota, Saint Paul, MN, USA; Department of Food Science and Nutrition, University of Minnesota, Saint Paul, MN, USA; Geriatric Research Education and Clinical Center, Minneapolis VA Health Care System, Minneapolis, MN, USA.
Minneapolis VA Health Care System · USUniversity of Minnesota · USUniversity of California, Los Angeles · US

Funding

PREDOCTORAL TRAINING OF NEUROSCIENTISTST32GM008471 · NIGMS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI EBNER, TIMOTHY J · 1993 to 2017
$4.9M
NIGMS NIH HHS T32 GM008471
6 · The paper itself

Abstract

backgroundAnimal welfare and accurate data collection are equally important in rodent research. Housing influences study outcomes and can challenge studies that monitor feeding, so housing choice needs to be evidence-based. The goal of these studies was to (1) compare established measures of well-being between rodents housed in wire grid-bottom floors with a resting platform compared to solid-bottom floors with bedding and (2) determine whether presence of a chewable device (Nylabone) affects orexin-A-induced hyperphagia.

methodsRodents were crossed over to the alternate housing twice after 2-week periods. Time required to complete food intake measurements was recorded as an indicator of feasibility. Food intake stimulated by orexin-A was compared with and without the Nylabone. Blood corticosterone and hypothalamic BDNF were assessed.

resultsHousing had no effect on growth, energy expenditure, corticosterone, hypothalamic BDNF, behavior, and anxiety measures. Food intake was disrupted after housing cross-over. Time required to complete food intake measurements was significantly higher for solid-bottom bedded cages. The Nylabone had no effect on orexin-A-stimulated feeding.

conclusionWell-being is not significantly different between rodents housed on grid-bottom floors and those in solid-bottom-bedded cages based on overall growth and feeding but alternating between housing confounds measures of feeding.

Indexed as

anxietycognitionenvironmental enrichmentmicroenvironmentstress

Identifiers

PMID26870735
PMCPMC4740365
OpenAlexW2273472121

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.