ArticleJournal of traditional and complementary medicine2016
Effects of the natural compounds embelin and piperine on the biofilm-producing property of Streptococcus mutans.
Article in Journal of traditional and complementary medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 67 citations in OpenAlex.
- A review of phytochemicals targeting bacterial biofilm and quorum sensing pathways: molecular, microbiological, and mechanistic insights.Archives of microbiology · 2026Review
- Plant Extracts Target Biofilms to Alleviate Nutritional and Metabolic Disorders in Animals.Veterinary sciences · 2026Review
- A Novel Agro-Waste Formulated Medium Enhanced the Growth of Electrogenic Enterobacter Species Isolated Using Microbial Fuel Cell System: Response Surface Methodology Approach.Environmental microbiology reports · 2025Article
- Dual role of piperine: Preserving the degree of conversion of resin cement on bleached enamel and exhibiting antimicrobial activity.Journal of clinical and experimental dentistry · 2025Review
- The Multifaceted Antimicrobial Profile of Piperine in Infectious Disease Management: Current Perspectives and Potential.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Effect of Polyherbal Toothpaste on Dental Plaque, Gingivitis, and Salivary Antioxidant Levels: A Single-blind Randomized Controlled Trial.International journal of clinical pediatric dentistry · 2025Article
- Exploration of Phytochemicals as Anti-biofilm Agents against Pathogenic Bacteria: Their Potential and Challenges.Infectious disorders drug targets · 2025Review
- Quorum Sensing Inhibitors: An Alternative Strategy to Win the Battle against Multidrug-Resistant (MDR) Bacteria.Molecules (Basel, Switzerland) · 2024Review
- Quorum Quenching Approaches against Bacterial-Biofilm-Induced Antibiotic Resistance.Antibiotics (Basel, Switzerland) · 2024Review
- Antibacterial and Anti-Quorum Sensing Properties of Silver Nanoparticles Phytosynthesized UsingPlants (Basel, Switzerland) · 2024Article
- Piperine-Loaded In Situ Gel: Formulation, In Vitro Characterization, and Clinical Evaluation against Periodontitis.Gels (Basel, Switzerland) · 2023Article
- Drugs for the Quorum Sensing Inhibition of Oral Biofilm: New Frontiers and Insights in the Treatment of Periodontitis.Pharmaceutics · 2022Review
- Antibacterial effects of natural compounds on biofilm formation of Streptococcus mutans.Clinical and experimental dental research · 2022Review
- Bacterial biofilms and their resistance mechanisms: a brief look at treatment with natural agents.Folia microbiologica · 2022Review
- Synergistic antimicrobial and antibiofilm activities of piperic acid and 4-ethylpiperic acid amides in combination with ciprofloxacin.The Journal of antibiotics · 2022Article
- Phytocompound Mediated Blockage of Quorum Sensing Cascade in ESKAPE Pathogens.Antibiotics (Basel, Switzerland) · 2022Review
- Quorum Sensing and NF-κB Inhibition of Synthetic Coumaperine Derivatives fromMolecules (Basel, Switzerland) · 2021Article
- Synergistic Antibiofilm Efficacy of Thymol and Piperine in Combination with Three Aminoglycoside Antibiotics againstThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2021Article
- Effectiveness of novel herbal dentifrice in control of plaque, gingivitis, and halitosis - Randomized controlled trial.Journal of traditional and complementary medicine · 2020Article
- Prevention of biofilm formation by quorum quenching.Applied microbiology and biotechnology · 2020Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We aimed to evaluate the effects of the natural compounds embelin and piperine on the biofilm-formation property of Streptococcus mutans. A total of 30 clinical isolates were identified as S. mutans and screened for biofilm formation using the microtiter plate method. The strongest biofilm producer (SM03) was used for identifying both minimum inhibitory concentration (MIC) and minimum biofilm inhibitory concentration (MBIC). We subsequently used this concentration against each of the strong biofilm producer isolates at A 492 < 0.5 optical density (OD). Of the 30 isolates screened for biofilm formation, 18 isolates showed strong biofilm formation, 09 isolates showed moderate formation, and 03 isolates showed poor/nonbiofilm formation. The MIC of embelin for the strongest biofilm producer (SM03) was 0.55 ± 0.02, whereas that of piperine was 0.33 ± 0.02. The MBIC of embelin was 0.0620 ± 0.03, whereas that of piperine was 0.0407 ± 0.03, which was lower than that of embelin. At OD492 < 0.5, the MBIC of both compounds significantly inhibited biofilm formation of all the 18 strong biofilm-forming isolates. The results of this study demonstrate a significant antibiofilm effect of the natural compounds embelin and piperine, which can contribute towards the development of a database for novel drug candidates for treating oral infections caused by S. mutans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.