ArticleResults in immunology2016
Ly6G-mediated depletion of neutrophils is dependent on macrophages.
Article in Results in immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed.
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- From Bench to Body: ProtectiveJournal of cellular immunology · 2025Article
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- Effects of injury size on local and systemic immune cell dynamics in volumetric muscle loss.bioRxiv : the preprint server for biology · 2024Article
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- Pathobiology of Candida auris infection analyzed by multiplexed imaging and single cell analysis.PloS one · 2024Article
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- Intravital microscopy of satellite cell dynamics and their interaction with myeloid cells during skeletal muscle regeneration.Science advances · 2023Article
- Complement, but Not Platelets, Plays a Pivotal Role in the Outcome of Mucormycosis In Vivo.Journal of fungi (Basel, Switzerland) · 2023Article
- Conditional Knockout of Hypoxia-Inducible Factor 1-Alpha in Tumor-Infiltrating Neutrophils Protects against Pancreatic Ductal Adenocarcinoma.International journal of molecular sciences · 2023Article
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- Pharmacological perturbation of CXCL1 signaling alleviates neuropathogenesis in a model of HEVA71 infection.Nature communications · 2022Article
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- Reduced Neutrophil Extracellular Trap Formation During Ischemia Reperfusion Injury in C3 KO Mice: C3 Requirement for NETs Release.Frontiers in immunology · 2022Article
- Monoclonal Antibody Requires Immunomodulation for Efficacy Against Acinetobacter baumannii Infection.The Journal of infectious diseases · 2021Article
- Maternal Neutrophil Depletion Fails to Avert Systemic Lipopolysaccharide-Induced Early Pregnancy Defects in Mice.International journal of molecular sciences · 2021Article
- uPA-PAI-1 heteromerization promotes breast cancer progression by attracting tumorigenic neutrophils.EMBO molecular medicine · 2021Article
- Cardiac macrophages prevent sudden death during heart stress.Nature communications · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Antibody-mediated depletion of neutrophils is commonly used to study neutropenia. However, the mechanisms by which antibodies deplete neutrophils have not been well defined. We noticed that mice deficient in complement and macrophages had blunted neutrophil depletion in response to anti-Ly6G monoclonal antibody (MAb) treatment. In vitro, exposure of murine neutrophils to anti-Ly6G MAb in the presence of plasma did not result in significant depletion of cells, either in the presence or absence of complement. In vivo, anti-Ly6G-mediated neutrophil depletion was abrogated following macrophage depletion, but not complement depletion, indicating a requirement for macrophages to induce neutropenia by this method. These results inform the use and limitations of anti-Ly6G antibody as an experimental tool for depleting neutrophils in various immunological settings.
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