ArticleNano research2015
An ultra-sensitive dual-mode imaging system using metal-enhanced fluorescence in solid phantoms.
Article in Nano research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Two-photon fluorescence lifetime imaging microscopy of NADH metabolism in HIV-1 infected cells and tissues.Frontiers in immunology · 2023Article
- Glutathione-capped gold nanoclusters as near-infrared-emitting efficient contrast agents for confocal fluorescence imaging of tissue-mimicking phantoms.Mikrochimica acta · 2022Article
- Design and Use of a Gold Nanoparticle-Carbon Dot Hybrid for a FLIM-Based IMPLICATION Nano Logic Gate.ACS omega · 2022Article
- Article
- Optimization of Gold Nanorod Features for the Enhanced Performance of Plasmonic Nanocavity Arrays.ACS omega · 2021Article
- Diffusion Reflection Measurements of Antibodies Conjugated to Gold Nanoparticles as a Method to Identify Cutaneous Squamous Cell Carcinoma Borders.Materials (Basel, Switzerland) · 2020Article
- Genetic Algorithm-Based Design for Metal-Enhanced Fluorescent Nanostructures.Materials (Basel, Switzerland) · 2019Article
- Tissue-Like Phantoms as a Platform for Inserted Fluorescence Nano-Probes.Materials (Basel, Switzerland) · 2016Article
- Nanoparticle-free tissue-mimicking phantoms with intrinsic scattering.Biomedical optics express · 2016Article
- Extremely sensitive dual imaging system in solid phantoms.Proceedings of SPIE--the International Society for Optical Engineering · 2016Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
In this study we developed a highly sensitive dual modal imaging system designed for gold nanoparticles (GNPs) conjugated to various fluorophores in solid phantoms. The system consists of fluorescence lifetime imaging microscopy (FLIM) for surface imaging, diffusion reflection (DR) for deep tissue imaging (up to 1cm), and metal enhanced fluorescence (MEF). We detected quenching in fluorescent intensity (FI) for the conjugation of gold nanospheres (GNS) as well as gold nanorods (GNRs) to Fluorescein, which has an excitation peak at a wavelength shorter than the surface plasmon resonance (SPR) of both types of GNPs, and enhanced FI in conjugation to Rhodamine B and Sulforhodamine B, both with excitation peaks in the GNPs' SPR. The enhanced FI was detected in solution as well as in solid phantoms from FLIM measurements. DR measurements detected GNR presence within the solid phantoms by recording dropped rates of light scattering using wavelengths corresponding to the GNRs' absorption. With the inclusion of MEF, this promising dual modal imaging technique enables efficient and sensitive molecular and functional imaging.
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Registered trials
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