ArticleOncology letters2016
Disappearance of giant cells and presence of newly formed bone in the pulmonary metastasis of a sacral giant-cell tumor following denosumab treatment: A case report.
Article in Oncology letters, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.
- The Evaluation and Management of Lung Metastases in Patients with Giant Cell Tumors of Bone in the Denosumab Era.Current oncology (Toronto, Ont.) · 2024Pooled it
- Denosumab for Effective Tumor Size Reduction in Patients With Giant Cell Tumors of the Bone: A Systematic Review and Meta-Analysis.Cancer control : journal of the Moffitt Cancer CenterPooled it
- Disappearance of histone H3F3A mutation in metastatic giant cell tumor of bone during long term follow up.Discover oncology · 2026Article
- Case Report: Unresectable pulmonary metastases of a giant cell tumor of bone treated with denosumab: a case report and review of literature.Frontiers in oncology · 2023Article
- Review
- Radiologic and clinical changes after denosumab treatment for giant cell tumors of the mobile spine: a quantitative study.Insights into imaging · 2022Article
- Review
- Radiomics on radiography predicts giant cell tumor histologic response to denosumab.Skeletal radiology · 2021Article
- Radiological findings of denosumab treatment for giant cell tumours of bone.Skeletal radiology · 2020Review
- In Vitro Study of the Effects of Denosumab on Giant Cell Tumor of Bone: Comparison with Zoledronic Acid.Pathology oncology research : POR · 2019Article
- Denosumab in Patients with Giant Cell Tumor and Its Recurrence: A Systematic Review.The archives of bone and joint surgery · 2018Review
- Expression and role of microRNA-1271 in the pathogenesis of osteosarcoma.Experimental and therapeutic medicine · 2018Article
- Surgical treatment outcome of giant cell tumor of distal ulna: En bloc resection vs. curettage and bone graft.Medical journal of the Islamic Republic of Iran · 2018Article
- Giant Cell Tumor of the Sacrum: Series of 19 Patients and Review of the Literature.The archives of bone and joint surgery · 2017Article
- Radiological and Histopathological Outcome of Giant Cell Tumor of Femur with Denosumab Treatment: A Case Report.Journal of clinical and diagnostic research : JCDR · 2016Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A giant-cell tumor of the bone (GCTB) is a benign but locally aggressive bone tumor. Recently, the receptor activator of nuclear factor κB (RANK) ligand inhibitor, denosumab, has demonstrated activity against giant-cell tumors. The current study reports a case of a sacral GCTB with lung metastasis. A 19-year-old male patient presented with right buttock pain and right lower leg pain, and a sacral GCTB was diagnosed based on the histological analysis of a biopsy specimen. The patient was successfully treated with neoadjuvant denosumab therapy, which allowed curettage. In addition, the pulmonary nodule reduced in size following denosumab administration, and surgical resection was performed. Since the operation, the patient has been managed with the continued use of denosumab with no sign of recurrence. Microscopic findings from the surgical specimen following denosumab treatment revealed that the giant cells had disappeared and woven bone had formed. The specimen from the pulmonary nodule exhibited similar findings to the surgical specimen. It was reported that denosumab treatment was able to reduce the number of giant cells and RANK-positive stromal cells, and cause the formation of new bone in the primary lesion. The present study reports the first case to demonstrate the efficiency of denosumab in treating pulmonary metastasis of GCTB.
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