ArticleOncology letters2016
Early tumor cavitation with regorafenib in metastatic colorectal cancer: A case report.
Article in Oncology letters, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 12 citations in OpenAlex.
- Radiological complete response with regorafenib for multiple lung metastases of ascending colon cancer: a case report.Journal of medical case reports · 2024Article
- Lung cavitation to pneumothorax: A case report of the multilayered respiratory challenges in oncology patients.International journal of surgery case reports · 2024Article
- Multiple cavitary lung lesions from colorectal cancer responding to chemotherapy.Respiratory medicine case reports · 2023Article
- Complete response of MSI-high metastatic colon cancer following treatment with regorafenib: A case report.Molecular and clinical oncology · 2021Article
- Serial Monitoring of Circulating Tumor DNA in Patients With Metastatic Colorectal Cancer to Predict the Therapeutic Response.Frontiers in genetics · 2019Article
- Metastatic colorectal cancer responsive to regorafenib for 2 years: a case report.Journal of medical case reports · 2017Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tumoral cavity formation is a characteristic phenomenon reported in anti-angiogenic therapy in lung lesions. A 57-year-old male with multiple pulmonary metastases from colorectal cancer treated with an oral tyrosine kinase inhibitor, regorafenib, exhibited a characteristic cavity formation after the first two cycles. The decrease in the size of tumors was calculated as 38%, and there were associated decreases in the serum concentrations of the tumor markers carcinoembryonic antigen and CA19-9. After eight cycles of treatment, the cavity gradually disappeared through filling-in. This unique morphological response is not only reported in lung cancer but also in liver metastasis in colorectal cancer. However, the association between morphological changes including cavity formation and clinical benefit remains controversial. Pulmonary hemorrhage and pneumothorax are well-known consequences of cavitation, as reported with the other anti-angiogenic inhibitors. Early tumor cavitation in lung metastasis may demonstrate the predictive potential of regorafenib in colorectal cancer, although it is necessary to be mindful of toxicity.
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Registered trials
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