ArticlePakistan journal of medical sciences
Association between thyroid hormone levels and insulin resistance and body mass index.
Article in Pakistan journal of medical sciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 15 citations in OpenAlex.
- Recombinant human thyrotropin reducing insulin resistance in patients with differentiated thyroid cancer.Journal of the Endocrine Society · 2026Article
- Thyroid Function Before and After Laparoscopic Sleeve Gastrectomy in Patients with Obesity.Obesity surgery · 2022Article
- Association between TSH levels within the reference range and adiposity markers at the baseline of the ELSA-Brasil study.PloS one · 2020Article
- The role of thyroid hormone in metabolism and metabolic syndrome.Therapeutic advances in endocrinology and metabolism · 2020Review
- Abnormal Glucose Metabolism and Insulin Resistance Are Induced via the IRE1α/XBP-1 Pathway in Subclinical Hypothyroidism.Frontiers in endocrinology · 2019Article
- Low total and free triiodothyronine levels are associated with insulin resistance in non-diabetic individuals.Scientific reports · 2018Article
- Circulating MicroRNA Profile as a Potential Predictive Biomarker for Early Diagnosis of Spontaneous Abortion in Patients With Subclinical Hypothyroidism.Frontiers in endocrinology · 2018Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivePrevious studies have shown an association between thyroid function and insulin resistance and obesity. We compared insulin resistance and body mass index (BMI) in patients with normal TSH levels (2.5-4.2 µIU/mL), patients diagnosed with subclinical hypothyroidism, and healthy control subjects.
methodsThe study included 104 subjects and was conducted at the Taksim Education and Research Hospital. The subjects were divided into three groups according to TSH levels: Group 1 (high-normal), TSH levels were 2.5-4.2 µIU/mL (n=33); Group 2 (subclinical hypothyroidism), TSH levels were 4.2-10 µIU/mL (n=42); and Group 3 (healthy control), TSH levels were 0.27-2.5 µIU/mL (n=29). The fT3 and fT4 levels were within normal limits in all groups. Insulin resistance and BMI were compared among groups. The homeostasis model assessment of insulin resistance (HOMA-IR) was used to estimate insulin resistance.
resultsHOMA-IR and BMI were not significantly different among groups (p>0.05). A significant positive correlation was found between BMI and HOMA-IR in the high-normal TSH (p>0.059) and subclinical hypothyroidism (p>0.05) groups.
conclusionsHOMA-IR and BMI are important for the assessment of diabetes and cardiovascular diseases. We found no significant difference in HOMA-IR and BMI values among the three TSH reference range groups.
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