Evidence map›Paper›PMID 26870028›Full record

ArticleFrontiers in microbiology2016

Antibodies Against Glycolipids Enhance Antifungal Activity of Macrophages and Reduce Fungal Burden After Infection with Paracoccidioides brasiliensis.

Renata A Bueno, Luciana Thomaz, Julian E Muñoz, Cássia J da Silva, Joshua D Nosanchuk, Márcia R Pinto, Luiz R Travassos, Carlos P Taborda

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

  1. The story of Paracoccidiodes gp43.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023
    Review
  2. Review
  3. Paracoccidioidomycosis Protective Immunity.Journal of fungi (Basel, Switzerland) · 2021
    Review
  4. Article
  5. Article
  6. Advances in Fungal Peptide Vaccines.Journal of fungi (Basel, Switzerland) · 2020
    Review
  7. Review
  8. The Trojan Horse Model inFrontiers in cellular and infection microbiology · 2020
    Review
  9. Article
  10. Article
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Renata A BuenoDepartment of Microbiology, Institute of Biomedical Sciences, University of São PauloSão Paulo, Brazil; Laboratory of Medical Mycology IMTSP- LIM53, University of São PauloSão Paulo, Brazil.
Luciana ThomazDepartment of Microbiology, Institute of Biomedical Sciences, University of São Paulo São Paulo, Brazil.
Julian E MuñozDepartment of Microbiology, Institute of Biomedical Sciences, University of São Paulo São Paulo, Brazil.
Cássia J da SilvaDepartment of Microbiology, Institute of Biomedical Sciences, University of São Paulo São Paulo, Brazil.
Joshua D NosanchukDepartment of Medicine, Albert Einstein College of Medicine, New YorkNY, USA; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New YorkNY, USA.
Márcia R PintoFluminense Federal University Niterói, Brazil.
Luiz R TravassosDepartment of Microbiology, Immunology and Parasitology, Federal University of São Paulo São Paulo, Brazil.
Carlos P TabordaDepartment of Microbiology, Institute of Biomedical Sciences, University of São PauloSão Paulo, Brazil; Laboratory of Medical Mycology IMTSP- LIM53, University of São PauloSão Paulo, Brazil.
Universidade de São Paulo · BRAlbert Einstein College of Medicine · USUniversidade Federal de São Paulo · BRUniversidade Federal Fluminense · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Paracoccidioidomycosis is a fungal disease endemic in Latin America. Polyclonal antibodies to acidic glycosphingolipids (GSLs) from Paracoccidioides brasiliensis opsonized yeast forms in vitro increasing phagocytosis and reduced the fungal burden of infected animals. Antibodies to GSL were active in both prophylactic and therapeutic protocols using a murine intratracheal infection model. Pathological examination of the lungs of animals treated with antibodies to GSL showed well-organized granulomas and minimally damaged parenchyma compared to the untreated control. Murine peritoneal macrophages activated by IFN-γ and incubated with antibodies against acidic GSLs more effectively phagocytosed and killed P. brasiliensis yeast cells as well as produced more nitric oxide compared to controls. The present work discloses a novel target of protective antibodies against P. brasiliensis adding to other well-studied mediators of the immune response to this fungus.

Indexed as

glycosphingolipidsnitric oxideParacoccidioides brasiliensisparacoccidioidomycosispolyclonal antibodies

Identifiers

PMID26870028
PMCPMC4737878
OpenAlexW2253182515

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.