ArticleFrontiers in microbiology2016
Comparative Genomic Analysis of the ICESa2603 Family ICEs and Spread of erm(B)- and tet(O)-Carrying Transferable 89K-Subtype ICEs in Swine and Bovine Isolates in China.
Article in Frontiers in microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
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- A New Composite Integrative and Conjugative Element Mediates Multiple Drug Resistance fromInfection and drug resistance · 2025Article
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- Comparative Genome Analysis of TwoAnimals : an open access journal from MDPI · 2024Article
- First WGS Characterization ofTransboundary and emerging diseases · 2024Article
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- Conjugative transfer of streptococcal prophages harboring antibiotic resistance and virulence genes.The ISME journal · 2023Article
- Various Mobile Genetic Elements Involved in the Dissemination of the Phenicol-Oxazolidinone Resistance GeneMicrobiology spectrum · 2023Article
- New Characterization of Multi-Drug Resistance ofAntibiotics (Basel, Switzerland) · 2023Article
- The antimicrobial systems ofVirulence · 2022Article
- How Streptococcus suis escapes antibiotic treatments.Veterinary research · 2022Review
- Characterization of a Novel Linezolid Resistance GeneMicrobiology spectrum · 2022Article
- Update on the Mechanisms of Antibiotic Resistance and the Mobile Resistome in the Emerging Zoonotic PathogenMicroorganisms · 2021Review
- Mobile Oxazolidinone Resistance Genes in Gram-Positive and Gram-Negative Bacteria.Clinical microbiology reviews · 2021Article
- Emergence of aFrontiers in veterinary science · 2021Article
- Horizontal Transfer of DifferentFrontiers in microbiology · 2021Article
- Predominance of III/ST19 and Ib/ST10 Lineages With High Multidrug Resistance in Fluoroquinolone-Resistant Group BFrontiers in microbiology · 2020Article
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Authors and funding
7 authors.
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Abstract
Integrative and conjugative elements (ICEs) of the ICESa2603 family have been isolated from several species of Streptococcus spp.; however, the comparative genomic and evolutionary analyses of these particular ICEs are currently only at their initial stages. By investigating 13 ICEs of the ICESa2603 family and two ICESa2603 family-like ICEs derived from diverse hosts and locations, we have determined that ICEs comprised a backbone of 30 identical syntenic core genes and accessory genes that were restricted to the intergenic sites or the 3'-end of the non-conserved domain of core genes to maintain its function. ICESa2603 family integrase IntICE Sa 2603 specifically recognized a 15-bp att sequence (TTATTTAAGAGTAAC) at the 3'-end of rplL, which was highly conserved in genus Streptococcus. Phylogenetic analyses suggest that extensive recombination/insertion and the occurrence of a hybrid/mosaic in the ICESa2603 family were responsible for the significant increase in ICE diversity, thereby broadening its host range. Approximately 42.5 and 38.1% of the tested Streptococcus suis and Streptococcus agalactiae clinical isolates respectively contained ICESa2603 family Type IV secretion system (T4SS) genes, and 80.5 and 62.5% of which also respectively carried int ICE Sa 2603, indicating that ICESa2603 family is widely distributed across these bacteria. Sequencing and conjugation transfer of a novel sequence type ST303 clinical S. suis isolate HB1011 demonstrated that the 89K-subtype ICESsuHB1011 retained its transferrable function, thereby conferring tetracycline and macrolide resistance.
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