ArticleFrontiers in microbiology2016
The TCA Pathway is an Important Player in the Regulatory Network Governing Vibrio alginolyticus Adhesion Under Adversity.
Article in Frontiers in microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- Review
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- Virulence regulation of ZnFrontiers in veterinary science · 2023Article
- Effect of the Type VI Secretion System Secreted Protein Hcp on the Virulence ofMicroorganisms · 2022Article
- Enhanced Hemolytic Activity of MesophilicMicroorganisms · 2022Article
- Potential dsRNAs can be delivered to aquatic for defense pathogens.Frontiers in bioengineering and biotechnology · 2022Review
- Article
- The regulation of oxidative phosphorylation pathway on Vibrio alginolyticus adhesion under adversities.MicrobiologyOpen · 2019Article
- Mechanisms underlying the virulence regulation of newEmerging microbes & infections · 2019Article
- Dual RNA-Seq UnveilsFrontiers in immunology · 2019Article
- Regulatory role of the RstB-RstA system in adhesion, biofilm production, motility, and hemolysis.MicrobiologyOpen · 2018Article
- secA, secD, secF, yajC, and yidC contribute to the adhesion regulation of Vibrio alginolyticus.MicrobiologyOpen · 2018Article
- mcp, aer, cheB, and cheV contribute to the regulation of Vibrio alginolyticus (ND-01) adhesion under gradients of environmental factors.MicrobiologyOpen · 2017Article
- Contributions of the oligopeptide permeases in multistep of Vibrio alginolyticus pathogenesis.MicrobiologyOpen · 2017Article
- AcuC, a histone deacetylase, contributes to the pathogenicity of Aeromonas hydrophila.MicrobiologyOpen · 2017Article
- flrA, flrB and flrC regulate adhesion by controlling the expression of critical virulence genes in Vibrio alginolyticus.Emerging microbes & infections · 2016Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adhesion is a critical step in the initial stage of Vibrio alginolyticus infection; therefore, it is important to understand the underlying mechanisms governing the adhesion of V. alginolyticus and determine if environmental factors have any effect. A greater understanding of this process may assist in developing preventive measures for reducing infection. In our previous research, we presented the first RNA-seq data from V. alginolyticus cultured under stress conditions that resulted in reduced adhesion. Based on the RNA-seq data, we found that the Tricarboxylic acid cycle (TCA pathway) might be closely related to adhesion. Environmental interactions with the TCA pathway might alter adhesion. To validate this, bioinformatics analysis, quantitative Real-Time PCR (qPCR), RNAi, and in vitro adhesion assays were performed, while V. alginolyticus was treated with various stresses including temperature, pH, salinity, and starvation. The expression of genes involved in the TCA pathway was confirmed by qPCR, which reinforced the reliability of the sequencing data. Silencing of these genes was capable of reducing the adhesion ability of V. alginolyticus. Adhesion of V. alginolyticus is influenced substantially by environmental factors and the TCA pathway is sensitive to some environmental stresses, especially changes in pH and starvation. Our results indicated that (1) the TCA pathway plays a key role in V. alginolyticus adhesion: (2) the TCA pathway is sensitive to environmental stresses.
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