ArticleFrontiers in psychology2016
Fusiform Gyrus Dysfunction is Associated with Perceptual Processing Efficiency to Emotional Faces in Adolescent Depression: A Model-Based Approach.
Article in Frontiers in psychology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 5 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 5 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Abnormalities of intrinsic brain activity in late-life depression: a meta-analysis of resting-state functional imaging studies.Translational psychiatry · 2026Pooled it
- The conscious processing of emotion in depression disorder: a meta-analysis of neuroimaging studies.Frontiers in psychiatry · 2023Pooled it
- An Emotion Recognition-Awareness Vulnerability Hypothesis for Depression in Adolescence: A Systematic Review.Clinical child and family psychology review · 2020Pooled it
- Abnormal amygdala resting-state functional connectivity in adults and adolescents with major depressive disorder: A comparative meta-analysis.EBioMedicine · 2018Pooled it
- Meta-Analysis of the RDoC Social Processing Domain across Units of Analysis in Children and Adolescents.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53Pooled it
- Aberrant resting-state functional connectivity in amygdala subregions among adolescents with depression and suicide attempts.World journal of psychiatry · 2026Article
- Adolescent depression recognition and symptom prediction based on multi-view EEG network: an exploratory study.Frontiers in psychiatry · 2026Article
- Machine learning and individual variability in electrical field characteristics predict tDCS treatment response for anxiety in older adults in the ACT trial.Frontiers in human neuroscience · 2026Article
- Altered effective connectivity of emotion perception and regulation networks during an emotional face perception task in adults with alcohol use disorder.Brain structure & function · 2025Article
- Neural Modulation Alteration to Positive and Negative Emotions in Depressed Patients: Insights from fMRI Using Positive/Negative Emotion Atlas.Tomography (Ann Arbor, Mich.) · 2024Article
- Abnormal activation patterns in MT+ during visual motion perception in major depressive disorder.Frontiers in psychiatry · 2024Article
- The Neuroimaging Role of Modified Electroconvulsive Therapy in the Major Depressive Disorder: Effectiveness in First-Episode Antipsychotic-Naive Major Depressive Disorder Patients.Depression and anxiety · 2024Article
- Aberrant single-subject morphological brain networks in first-episode, treatment-naive adolescents with major depressive disorder.Psychoradiology · 2023Article
- The amplitude of low-frequency fluctuation characteristics in depressed adolescents with suicide attempts: a resting-state fMRI study.Frontiers in psychiatry · 2023Article
- Residential green space and air pollution are associated with brain activation in a social-stress paradigm.Scientific reports · 2022Article
- Deficient prefrontal-amygdalar connectivity underlies inefficient face processing in adolescent major depressive disorder.Translational psychiatry · 2022Article
- Abnormal Functional Network Topology and Its Dynamics during Sustained Attention Processing Significantly Implicate Post-TBI Attention Deficits in Children.Brain sciences · 2021Article
- The additive effect of late-life depression and olfactory dysfunction on the risk of dementia was mediated by hypersynchronization of the hippocampus/fusiform gyrus.Translational psychiatry · 2021Article
- Alterations in intrinsic functional networks in Parkinson's disease patients with depression: A resting-state functional magnetic resonance imaging study.CNS neuroscience & therapeutics · 2021Article
- Abnormal large-scale resting-state functional networks in drug-free major depressive disorder.Brain imaging and behavior · 2021Article
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
While the extant literature has focused on major depressive disorder (MDD) as being characterized by abnormalities in processing affective stimuli (e.g., facial expressions), little is known regarding which specific aspects of cognition influence the evaluation of affective stimuli, and what are the underlying neural correlates. To investigate these issues, we assessed 26 adolescents diagnosed with MDD and 37 well-matched healthy controls (HCL) who completed an emotion identification task of dynamically morphing faces during functional magnetic resonance imaging (fMRI). We analyzed the behavioral data using a sequential sampling model of response time (RT) commonly used to elucidate aspects of cognition in binary perceptual decision making tasks: the Linear Ballistic Accumulator (LBA) model. Using a hierarchical Bayesian estimation method, we obtained group-level and individual-level estimates of LBA parameters on the facial emotion identification task. While the MDD and HCL groups did not differ in mean RT, accuracy, or group-level estimates of perceptual processing efficiency (i.e., drift rate parameter of the LBA), the MDD group showed significantly reduced responses in left fusiform gyrus compared to the HCL group during the facial emotion identification task. Furthermore, within the MDD group, fMRI signal in the left fusiform gyrus during affective face processing was significantly associated with greater individual-level estimates of perceptual processing efficiency. Our results therefore suggest that affective processing biases in adolescents with MDD are characterized by greater perceptual processing efficiency of affective visual information in sensory brain regions responsible for the early processing of visual information. The theoretical, methodological, and clinical implications of our results are discussed.
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